低分子肝素治疗妊娠期肾病综合征高凝状态患者的作用分析

Effect of low molecular weight heparin on hypercoagulable state of nephrotic syndrome during pregnancy

目的分析低分子肝素在妊娠期肾病综合征高凝状态患者中的应用价值。方法选取86例妊娠期肾病综合征高凝状态患者,根据随机抽签法分为对照组与研究组,每组43例。研究组采用低分子肝素联合常规治疗,对照组采用常规治疗。对比两组患者凝血功能指标、妊娠延长天数及出血量。结果治疗前,两组凝血酶原时间(PT)、活化部分凝血酶原时间(APTT)、纤维蛋白原(FIB)、D-二聚体(D-D)、抗凝血酶Ⅲ(AT-Ⅲ)及红细胞压积(HCT)指标比较,差异无统计学意义(P>0.05);治疗后,研究组PT、APTT指标长于对照组,FIB、D-D、HCT指标低于对照组,AT-Ⅲ指标高于对照组,差异具有统计学意义(P<0.05)。研究组妊娠延长天数(15.40±3.20)d长于对照组(10.36±2.60)d,出血量(332.75±8.15)ml少于对照组(345.55±8.12)ml(P<0.05)。结论在治疗妊娠期肾病综合征高凝状态患者期间,采用低分子肝素治疗,有利于改善患者凝血功能,延长妊娠时间。

Objective To analyze the application value of low molecular weight heparin in patients with hypercoagulable state of nephrotic syndrome during pregnancy.Methods 86 patients with hypercoagulable state of nephrotic syndrome during pregnancy were selected and divided into control group and study group according to random drawing method,with 43 cases in each group.The study group received low molecular weight heparin combined with conventional treatment,and the control group received conventional treatment.Coagulation function indexes,extended gestation days and blood loss were compared between the two groups.Results Before treatment,there were no significant differences in prothrombin time(PT),activated partial prothrombin time(APTT),fibrinogen(FIB),D-dimer(D-D),antithrombinⅢ(AT-Ⅲ)and hematopoietic volume(HCT)between 2 groups(P>0.05).After treatment,PT and APTT indexes in the study group were higher than those in the control group,FIB,D-D and HCT indexes were lower than those in the control group,and AT-Ⅲindexes were higher than those in the control group,the difference was statistically significant(P<0.05).The extended gestation days(15.40±3.20)d in the study group were longer than those in the control group(10.36±2.60)d,and the blood loss(332.75±8.15)ml was less than that in the control group(345.55±8.12)ml(P<0.05).Conclusion Low molecular weight heparin therapy during the treatment of hypercoagulable state in patients with nephrotic syndrome during pregnancy is beneficial to improve the coagulation function of patients and prolong pregnancy.