通胞化瘀灌肠合剂治疗湿热瘀结型慢性盆腔炎的临床体会

Clinical experience of Tongbaohuayu enema mixture in treating chronic pelvic inflammatory disease of dampness-heat stasis

目的探讨通胞化瘀灌肠合剂治疗湿热瘀结型慢性盆腔炎的临床效果。方法选取600例湿热瘀结型慢性盆腔炎患者,按照随机抽签法将其分为研究组与对照组,各300例。对照组采用左氧氟沙星联合奥硝唑胶囊治疗,研究组采用通胞化瘀灌肠合剂治疗。对比两组治疗前后中医证候积分、炎症因子及不良反应发生情况。结果治疗前,两组中医证候评分比较,差异无统计学意义(P>0.05);治疗后,研究组中医证候评分明显低于对照组(P<0.05)。治疗前,两组肿瘤坏死因子(TNF-α)、C-反应蛋白(CRP)及白介素-8(IL-8)水平比较,差异无统计学意义(P>0.05);治疗后,两组TNF-α、CRP及IL-8水平均较治疗前有所下降,且研究组明显低于对照组(P<0.05)。研究组不良反应发生率为2.33%,明显低于对照组的5.67%,差异有统计学意义(P<0.05)。结论通胞化瘀灌肠合剂治疗湿热瘀结型慢性盆腔炎疾病效果确切,可缓解临床症状,降低中医证候评分,减少不良反应发生,利于预后,值得临床推广与应用。

Objective To explore the clinical effect of Tongbaohuayu enema mixture in treating chronic pelvic inflammatory disease with dampness-heat stasis.Methods 600 cases of chronic pelvic inflammatory disease with dampness-heat stasis were selected and divided into study group and control group with 300 cases each according to random drawing method.The control group was treated with levofloxacin combined with ornidazole capsule,and the study group was treated with Tongbaohuayu enema mixture.TCM syndrome scores,inflammatory factors and adverse reactions were compared between the two groups before and after treatment.Results Before treatment,there was no significant difference in TCM syndrome scores between the two groups(P>0.05).After treatment,the TCM syndrome score of the study group was significantly lower than that of the control group(P<0.05).Before treatment,there was no significant difference in tumor necrosis factor(TNF-α),C-reactive protein(CRP)and interleukin-8(IL-8)levels between the two groups(P>0.05).After treatment,the levels of TNF-α,CRP and IL-8 in both groups were decreased compared with those before treatment,and the levels in study group were significantly lower than those in control group(P<0.05).The incidence of adverse reactions in the study group was 2.33%,which was significantly lower than that in the control group(5.67%),the difference was statistically significant(P<0.05).Conclusion Tongbaohuayu enema mixture is effective in treating chronic pelvic inflammatory disease with dampness-heat stasis.It can relieve clinical symptoms,reduce TCM syndrome score,reduce adverse reactions,and is beneficial to prognosis.It is worthy of clinical promotion and application.