Revolution低剂量CT扫描定量评估与慢性阻塞性肺疾病严重程度的相关性研究

Correlation Between Quantitative Evaluation of Revolution Low-dose CT Scan and the Severity of Chronic Obstructive Pulmonary Disease

目的研究Revolution低剂量CT扫描定量评估与慢性阻塞性肺疾病(COPD)严重程度的相关性。方法以2021年12月-2022年12月石嘴山市第一人民医院收治的83例COPD患者为研究对象,其中GOLD分级Ⅰ级18例、Ⅱ级31例、Ⅲ级22例、Ⅳ级12例,所有患者均给予Revolution低剂量CT扫描定量评估,获取CT定量参数[气道管腔面积(LA)、管壁面积(WA)、管壁厚度(WT)、气道内周径10 mm时的管壁厚度(Pi10)、支气管管腔容积(LV)],比较不同GOLD分级患者的CT定量参数与肺功能指标[1 s用力呼气容积(FEV_(1))、用力肺活量(FVC)、1 s率(FEV_(1)/FVC)],并分析CT定量参数与肺功能指标的相关性。结果不同GOLD分级患者的WA、WT、Pi10、LV比较,差异有统计学意义(P<0.05),其中,WA、WT、Pi10由高至低依次为Ⅳ级>Ⅲ级>Ⅱ级>Ⅰ级,LV由高至低依次为Ⅰ级>Ⅱ级>Ⅲ级>Ⅳ级;不同GOLD分级患者的FEV_(1)、FVC、FEV_(1)/FVC比较,差异有统计学意义(P<0.05),其FEV_(1)、FVC、FEV_(1)/FVC由高至低依次为Ⅰ级>Ⅱ级>Ⅲ级>Ⅳ级。Pearson相关性分析显示,WA、Pi10与FEV_(1)、FVC、FEV_(1)/FVC呈负相关(P<0.05),LV与FEV_(1)、FVC、FEV_(1)/FVC呈正相关(P<0.05)。结论Revolution低剂量CT扫描定量参数WA、Pi10、LV与COPD患者的肺功能存在相关性,对该病严重程度具有一定的评估价值。

Objective To study the correlation between the quantitative evaluation of Revolution low-dose CT scan and the severity of chronic obstructive pulmonary disease(COPD).Methods A total of 83 patients with COPD admitted to the First People's Hospital of Shizuishan from December 2021 to December 2022 were enrolled in the study,including 18 cases of GOLD gradeⅠ,31 cases of GOLD gradeⅡ,22 cases of GOLD gradeⅢ,and 12 cases of GOLD gradeⅣ.All patients were given Revolution low-dose CT scan quantitative evaluation to obtain CT quantitative parameters[airway lumen area(LA),wall area(WA),wall thickness(WT),wall thickness at 10 mm airway circumference(Pi10),bronchial lumen volume(LV)].The CT quantitative parameters and lung function indexes[1 s forced expiratory volume(FEV_(1)),forced vital capacity(FVC),forced expiratory volume in one second/forced vital capacity(FEV_(1)/FVC)]of patients with different GOLD grades were compared,and the correlation between CT quantitative parameters and lung function indexes was analyzed.Results There were significant differences in WA,WT,Pi10 and LV among patients with different GOLD grades(P<0.05),among them,the parameters of WA,WT and Pi10 ranked from high to low as gradeⅣ>gradeⅢ>gradeⅡ>gradeⅠ,and the LV parameters ranked from high to low as gradeⅠ>gradeⅡ>gradeⅢ>gradeⅣ.There were significant differences in FEV_(1),FVC and FEV_(1)/FVC among patients with different GOLD grades(P<0.05),among them,the FEV_(1),FVC and FEV_(1)/FVC indexes ranked from high to low as gradeⅠ>gradeⅡ>gradeⅢ>gradeⅣ.Pearson correlation analysis showed that WA and Pi10 were negatively correlated with FEV_(1),FVC and FEV_(1)/FVC(P<0.05),and LV was positively correlated with FEV_(1),FVC and FEV_(1)/FVC(P<0.05).Conclusion The quantitative parameters WA,Pi10 and LV of Revolution low-dose CT scan are correlated with lung function in patients with COPD,and have certain evaluation value for the severity of the disease.