摘要
Achieving efficient integration of cancer diagnosis and therapy is of great significance to human health,but the construction of a multifunctional intelligent therapy system still faces great challenges.In this study,we report an integrated multifunctional nanocomposite constructed by a simple modular assembly technology.The nanocomposites are composed of three different nanomaterials:Fe_(3)O_(4),Au,and NaErF_(4):0.5%Tm@NaYF_(4)upconversion nanoparticles(UCNPs).In this design,Fe_(3)O_(4)nanoparticles have nanozyme effect of peroxidase-like activity,which can react with H_(2)O_(2)in the tumor microenvironment to generate hydroxyl radicals.Because of its magnetic properties,it can help the nanocomposites to aggregate under the induction of magnetic fields.Au nanoparticles exhibit nanozyme effect of glucose oxidase-like activity.It can catalyze the conversion of glucose to gluconic acid and H_(2)O_(2).Ingeniously,the generated H_(2)O_(2)provides a source of reactants for the reaction of the Fe_(3)O_(4)nanozyme.In addition,the photothermal effect of Au nanoparticles under 808 nm irradiation further enhanced the nanozyme activity of Fe_(3)O_(4)and Au nanoparticles.Besides,UCNPs can emit near-infrared(NIR)-II fluorescence under 808 nm irradiation,which can provide imaging-guided during cancer treatment.Then,the nanocomposites were further modified by poly(vinylpyrrolidone)(PVP)to obtain UCNPs/Au/Fe_(3)O_(4)-PVP with good biocompatibility and high-efficiency cancer treatment ability.
基金
This work was supported by the financial aid from the National Natural Science Foundation of China(Nos.22020102003,21834007,and 52103276)
the National Key R&D Program of China(No.2020YFA0712102)
the Program of Science and Technology Development Plan of Jilin Province of China(No.20220508076RC)
the Natural Science Foundation of Guangdong Province of China(No.2022A1515010947)
Guangzhou Basic and Applied Basic Research Foundation(No.202201011343).
