阻塞性睡眠呼吸暂停低通气综合征患者围术期实施无创正压通气治疗的临床价值

Clinical Value of Noninvasive Positive Pressure Ventilation in Patients with Obstructive Sleep Apnea Hypopnea Syndrome During Perioperative Period

目的:探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者围术期实施无创正压通气治疗的效果。方法:选取2019年1月—2022年7月遵义医科大学附属医院收治的OSAHS患者70例为观察对象,根据随机数字表法分为对照组与试验组,各35例。对照组给予常规治疗,试验组给予无创正压通气治疗。比较两组治疗效果。结果:治疗后,试验组平均动脉压高于对照组,心率及呼吸频率低于对照组,差异有统计学意义(P<0.001)。试验组治疗总有效率高于对照组,差异有统计学意义(P=0.002)。治疗后,试验组C反应蛋白、白细胞介素-6、白细胞计数、降钙素原水平低于对照组,差异有统计学意义(P<0.001)。试验组不良反应发生率低于对照组,差异有统计学意义(P=0.012)。结论:OSAHS患者围术期实施无创正压通气治疗可改善患者呼吸状况,减轻身体炎性反应,不良反应少,安全性高,能够促进病情康复。

Objective:To investigate the effect of noninvasive positive pressure ventilation in patients with obstructive sleep apnea hypopnea syndrome(OSAHS)during perioperative period.Methods:A total of 70 OSAHS patients treated in the Affiliated Hospital of Zunyi Medical University from January 2019 to July 2022 were selected as the observation objects,and they were divided into control group and observation group according to the random number table method,with 35 cases in each group.The control group was given conventional treatment,and the experimental group was given noninvasive positive pressure ventilation treatment.The treatment effects were compared between the two groups.Results:After treatment,the mean arterial pressure in the experimental group was higher than that in the control group,and the heart rate and respiratory rate in the experimental group were lower than those in the control group,and the difference was statistically significant(P<0.001).The total effective rate of treatment in the experimental group was higher than that in the control group,and the difference was statistically significant(P=0.002).After treatment,the levels of C-reactive protein,interleukin-6,white blood cell count,and procalcitonin in the experimental group were lower than those in the control group,and the difference was statistically significant(P<0.001).The incidence of adverse reactions in the experimental group was lower than that in the control group,and the difference was statistically significant(P=0.012).Conclusion:Perioperative noninvasive positive pressure ventilation treatment in OSAHS patients can improve the respiratory condition,reduce the inflammatory reaction,induce fewer adverse reactions,with a high safety,and promote the rehabilitation.