阿司匹林联合他汀类药物治疗脑血栓的效果观察

Effect Observation of Aspirin Combined with Statins in Treatment of Cerebral Thrombosis

目的:探讨阿司匹林联合他汀类药物治疗脑血栓的效果。方法:选取2020年7月—2021年8月济南市莱芜区羊里街道社区卫生服务中心收治的106例脑血栓患者作为研究对象,随机分为两组,各53例。对照组给予阿司匹林治疗,研究组在对照组基础上给予阿托伐他汀钙治疗。比较两组治疗效果、不良反应发生情况、动脉斑块改善情况、神经功能改善情况。结果:研究组治疗总有效率高于对照组,不良反应发生率低于对照组,差异有统计学意义(P<0.05)。治疗前,两组斑块面积、颈动脉内膜中层厚度比较,差异无统计学意义(P>0.05);治疗后,研究组斑块面积、颈动脉内膜中层厚度均小于对照组,差异有统计学意义(P<0.001)。治疗前,两组美国国立卫生研究院卒中量表(NIHSS)评分比较,差异无统计学意义(P>0.05);治疗后,两组NIHSS评分均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.001)。结论:阿司匹林联合他汀类药物治疗脑血栓的效果显著,可改善神经功能,缩小动脉斑块面积及颈动脉内膜中层厚度,且不良反应较少,安全性高,建议临床应用并予以推广。

Objective:To explore the effect of aspirin combined with statins in treatment of cerebral thrombosis.Methods:A total of 106 patients with cerebral thrombosis who were admitted to Yangli Street Community Health Service Center in Laiwu District of Jinan City from July 2020 to August 2021 were selected as the study subjects.They were randomly divided into two groups,with 53 cases in each group.The control group was treated with aspirin and the study group was treated with atorvastatin calcium on the basis of the control group.The treatment effect,occurrence of adverse reactions,improvement of arterial plaque and improvement of neurological function were compared between the two groups.Results:The total effective rate of treatment in the study group was higher than that in the control group,and the incidence of adverse reactions in the study group was lower than that in the control group,and the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in plaque area and carotid intima thickness between the two groups(P>0.05).After treatment,the plaque area and carotid intima thickness in the study group were lower than those in the control group,and the differences were statistically significant(P<0.001).Before treatment,there was no significant difference in the National Institutes of Health Stroke Scale(NIHSS)scores between the two groups(P>0.05).After treatment,the NIHSS scores in two groups were lower than those before treatment,and the study group was lower than the control group,and the difference was statistically significant(P<0.001).Conclusion:The aspirin combined with statins has a significant effect in the treatment of cerebral thrombosis.It can improve the neurological function,reduce the arterial plaque area and carotid intima thickness,with fewer adverse reactions and high safety,and it is worthy of clinical application and promotion.