巨噬细胞在放射相关性肺炎和肺纤维化中的研究进展

Research Progress of Macrophages in Development of Radiation Pneumonitis and Pulmonary Fibrosis

放射相关性肺炎及肺纤维化是胸部肿瘤患者接受放射治疗的重要剂量限制性毒性反应,影响患者的预后和生活质量。免疫系统的调控紊乱,尤其是巨噬细胞的功能失衡在其中发挥着重要作用。随着巨噬细胞的趋化和极化,它在诱导炎性细胞浸润、炎性因子和促纤维化因子释放,以及促进细胞外基质沉积和肺组织结构重塑等过程的分子机制逐渐被阐释,靶向巨噬细胞进行预防和控制放疗后肺损伤的研究也逐渐增多。本文就巨噬细胞在放射相关性肺炎和肺纤维化中的研究进展以及潜在的药物应用进行综述。

Radiation pneumonitis and pulmonary fibrosis are important dose-limiting side effects of radiotherapy that influence the prognosis and quality of life of patients with thoracic cancer.The disorder of the immune system plays a key role,especially macrophages.With the discovery of underlying molecular mechanisms,including the chemotaxis and polarization of macrophages,the infiltration of inflammatory cells,the release of inflammatory and pro-fibrotic factors,extracellular matrix deposition and the remodeling of lung structure,increasing strategies are under investigation to facilitate the prevention or treatment of lung injury via targeting macrophages.In this paper,the role of macrophages in the development of radiation pneumonitis,pulmonary fibrosis,and potential drug use strategies were reviewed.