摘要
越来越多的研究表明长链非编码RNA(long non-coding RNA,lncRNA)在内皮细胞损伤、炎症、癌症及自身免疫性疾病中发挥重要作用。系统性硬化症(systemic sclerosis,SSc)是一种发病机制尚未明确的自身免疫性疾病,而研究人员发现lncRNA可能通过调控免疫失调、微血管病变以及纤维化等过程参与SSc的发生和发展,还可能作为SSc的生物标志物来预测疾病的发生、活性程度以及进展阶段,因此可为SSc提供新的治疗靶点。
Accumulating studies have shown that long non-coding RNA(lncRNA)plays major roles in endothelial injury,inflammation,cancer,and autoimmune diseases.Systemic sclerosis(SSc)is an autoimmune disease with an unclear pathogenesis.lncRNA may be involved in the occurrence and development of SSc by regulating immune disorders,microvascular disease,and fibrosis,and may be a biomarker of SSc to predict occurrence,activity and progression of the disease.Therefore,lncRNA may be a novel therapeutic target of SSc.
作者
王宝玥
王永福
孙晓林
WANG Baoyue;WANG Yongfu;SUN Xiaolin(Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou 014010,China.;Central Laboratory of the First Affiliated Hospital of Baotou Medical College,Inner Mongolia University of Science and Technology(Key Laboratory of Autoimmunity of Inner Mongolia),Baotou 014010.;Department of Rheumatology,the First Affiliated Hospital of Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou 014010)
出处
《中国比较医学杂志》
CAS
北大核心
2023年第7期141-148,共8页
Chinese Journal of Comparative Medicine
基金
国家自然科学基金资助项目(81860294)
内蒙古自治区自然科学基金资助项目(2019MS08055,2021MS08045)
内蒙古自治区科技计划项目(201802089,2019GG052)。
