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磷酸西格列汀联合二甲双胍治疗初发2型糖尿病的效果分析 被引量:2

Efficacy of Sitagliptin Phosphate Combined with Metformin in the Treatment of Incipient Type 2 Diabetes Mellitus
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摘要 目的:探讨磷酸西格列汀联合二甲双胍治疗初发2型糖尿病的临床效果。方法:选取2021年4月—2022年3月山东省东明县中医医院收治的初发2型糖尿病患者86例为观察对象,根据随机数字表法均分为对照组与观察组,各43例。对照组给予二甲双胍治疗,观察组给予磷酸西格列汀联合二甲双胍治疗。比较两组患者治疗效果。结果:观察组患者治疗总有效率高于对照组,差异有统计学意义(P=0.02)。治疗后,两组患者空腹血糖、餐后2 h血糖水平均降低,且观察组低于对照组,差异有统计学意义(P<0.05)。观察组不良反应发生率低于对照组,差异有统计学意义(P=0.01)。结论:磷酸西格列汀与二甲双胍联合应用可有效降低初发2型糖尿病患者的血糖水平,提高临床治疗效果,不良反应发生率低。 Objective:To investigate the clinical effect of sitagliptin phosphate combined with metformin in the treatment of incipient type 2 diabetes.Methods:A total of eighty-six patients with newly diagnosed type 2 diabetes treated in Dongming County Hospital of Traditional Chinese Medicine from April 2021 to March 2022 were selected as the observation objects,and were divided into control group and observation group according to random number table method,with forty-three cases in each group.The control group was treated with metformin,and the observation group was treated with sitagliptin phosphate combined with metformin.The therapeutic effect of the two groups was compared.Results:The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P=0.02).After treatment,the fasting blood glucose and 2 h postprandial blood glucose levels in 2 groups were decreased,and the observation group was lower than the control group,the difference was statistically significant(P<0.05).The incidence of adverse reactions in observation group was lower than that in control group,and the difference was statistically significant(P=0.01).Conclusion:The combination of sitagliptin phosphate and metformin can effectively reduce the blood glucose level in patients with incipient type 2 diabetes,improve the clinical therapeutic effect,and reduce the incidence of adverse reactions.
作者 鲁艳丽 Lu Yan-li(Department of Pharmacy,Dongming County Hospital of Traditional Chinese Medicine,Heze 274500,Shandong Province,China)
出处 《中外医药研究》 2023年第5期33-35,共3页 JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH
关键词 磷酸西格列汀 二甲双胍 初发2型糖尿病 Sitagliptin phosphate Metformin Incipient of type 2 diabetes
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