定量CT对无酗酒者肝脏脂肪含量的测量 及对肝脏脂肪含量影响因素的研究

Measurement of liver fat content in nonalcoholic subjects and study on liver fat content’s influencing factors by quantitative CT

目的:通过定量CT测量肝脏脂肪含量,分析无酗酒者肝脏脂肪含量的影响因素,为非酒精性脂肪肝(NAFL)的无创诊断和防治提供依据。方法:回顾性分析行定量CT扫描的277例受检者,使用QCT测量软件测量所有受检者的腹部皮下脂肪面积(SAA)、腹腔内脂肪面积(VAA)、肝脏脂肪含量、骨密度,测量并计算肝脾CT值比值,分析无酗酒者的肝脏脂肪含量与血脂、血糖、血压、年龄、性别、骨密度、SAA、VAA及肝脏CT值、肝脾CT值比值的相关性。结果:血脂、血糖、血压、骨密度、SAA、VAA与肝脏脂肪含量呈正相关,其中肝脏脂肪含量与血脂、VAA呈中度相关(r=0.466,0.422)。肝脏脂肪含量与肝脏CT值、肝脾CT值比值呈显著负相关(r=-0.961,-0.913),肝脏脂肪含量与肝脏CT值、肝脾CT值比值存在线性关系,线性回归方程分别为y=40.86-0.57x,y=37.98-27.29x。结论:肝脏CT值、肝脾CT值比值均可较好地反映肝脏脂肪含量,可应用于NAFL筛查和相关研究中。血脂、血糖、血压、骨密度、SAA、VAA是肝脏脂肪含量的正性相关因素。定量CT可为NAFL的无创诊断和防治提供依据。

Objective:To measure the liver fat content and explore the influencing factors of liver fat content in nonalcoholics by quantitative CT(QCT).To provide a basis for the noninvasive diagnosis and prevention of nonalcoholic fatty liver(NAFL).Methods:A total of 277 subjects who underwent QCT scans were retrospectively analyzed.The subjects’subcutaneous adipose area(SAA),visceral adipose area(VAA),liver fat content and bone mineral density(BMD)were measured by QCT measurement software.The liver-spleen CT ratio was measured and calculated.The correlations between liver fat content and blood lipid,glucose,blood pressure,age,sex,BMD,SAA,VAA,liver CT value,liver-spleen CT ratio were analyzed.Results:The blood lipid,glucose,blood pressure,BMD,SAA,and VAA were positively correlated with liver fat content,and liver fat content was moderately correlated with blood lipid and VAA(r=0.466,0.422).Liver fat content was negatively correlated with liver CT value and liver-spleen CT ratio(r=-0.961,-0.913).There was a linear relation between liver fat content and liver CT value and between liver fat content and liver-spleen CT ratio.The linear regression equations were y=40.86-0.57x and y=37.98-27.29x.Conclusions:Liver CT value and liver-spleen CT ratio can reflect the liver fat content well and can be used in NAFL screening and research.The blood lipid,glucose,blood pressure,BMD,SAA and VAA are positively correlated with liver fat content.QCT can provide a basis for the noninvasive diagnosis and prevention of NAFL.