SARS-CoV-2细胞受体的研究进展

Recent progress on cell receptors for SARS-CoV-2

严重急性呼吸综合征冠状病毒2(severe acute respiratory syndrome coronavirus 2,SARS-CoV-2)是引起2019冠状病毒病(coronavirus disease 2019,COVID-19)的病原体,在人群中广泛持久传播,对人类健康和社会经济造成了巨大危害。目前,针对COVID-19的治疗尚无特异高效的抗病毒药物。病毒为实现寄生感染,通常先与宿主细胞膜表面受体结合,进而内化入胞。因此,SARS-CoV-2受体决定着病毒的感染特性和宿主范围,对其进行研究和解析是战胜SARS-CoV-2感染的一个关键手段。SARS-CoV-2受体的发现和鉴定,将为COVID-19提供新的治疗靶点。本文主要对SARS-CoV-2入侵受体及黏附受体的研究进展进行综述。

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the causative agent of the coronavirus disease 2019(COVID-19),which spreads rapidly in humans and endangers global health and economy.There are no specific and effective antiviral drugs for the treatment of COVID-19 currently.To infect host cells successfully for a virus,receptor binding and virus internalization are considered to be the initial steps.A key to combat SARS-CoV-2 infection is to investigate the viral receptors,which determine its infectivity and host range.The discovery and identification of cell receptors for SARS-CoV-2 will provide new therapeutic targets for COVID-19.This article reviews the recent findings on the entry and attachment receptors for SARS-CoV-2.