结核分枝杆菌细胞壁脂质成分生物活性的研究进展

Progress on bioactivity of lipids of Mycobacterium tuberculosis cell wall

结核分枝杆菌(Mycobacterium tuberculosis)作为全球流行性、慢性传染病结核病的病原体,其致病机制、耐药性与其特异性细胞壁成分密切相关,尤其是脂质成分,如脂阿拉伯甘露聚糖、海藻糖二霉菌酸酯、酚糖脂等糖脂类。因此,结核分枝杆菌细胞壁脂质成分的相关研究对结核病的诊断、防治具有重要价值。本文对结核分枝杆菌细胞壁部分脂质成分的生物学活性作一综述,以期为结核分枝杆菌相关基础研究提供参考。

Mycobacterium tuberculosis(M.tuberculosis)is the pathogen of tuberculosis,a global epidemic and chronic infectious disease.Its pathogenic mechanism and drug resistance are closely related to its specific cell wall components,especially lipids,such as lipoarabinomannans,trehalose-6,6’-dimycolates,phenolic glycolipids and other glycolipids.It is of great value to study the lipids of M.tuberculosis cell wall for the diagnosis and prevention of tuberculosis.In order to provide a reference for the related basic research of M.tuberculosis,this review summarized the recent progress on the bioactivity of various lipids of M.tuberculosis cell wall.