摘要
In the new issue of Cell,Dr.Meisel’s teamcharacterized how the orally administrated probiotic bacteria Lactobacillus reuteri(Lr)translocated from the gut to tumors in mice with melanoma.1 Furthermore,its production of a compound called indole-3-aldehyde(I3A)derived fromdietary tryptophan directly stimulates immune cells to make cancer immunotherapy more effective(Figure 1A).
基金
the financial support for this research received fromthe Health and Medical Research Fund of Hong Kong(10212276)
National Natural Science Foundation of China(Nos.32071301,32111530179,32270886,and 32070827)
National Key R&D Program of China(2022YFA1106400 and 2020YFA0803201)
Key laboratory tasks(LG202103-01-07)
Youth Innovation Promotion Association of CAS(2021264)
Shanghai Natural Science Foundation(22ZR1469800)
Outstanding Youth Reserve Talent Project(IDF201370/074)
Scientific Research Foundation for the introduction of talent(JIF201035Y).
