炎症生化指标与宫颈癌临床病理特征的关系探讨

Inquire into relationship between biochemical markers of inflammation and clinico-pathological characteristics of uterine cervical cancer

目的探讨炎症生化指标与宫颈癌临床病理特征之间的关系,辅助临床评估宫颈癌疾病进展与预后。方法选取2018年6月~2022年7月在华北理工大学附属医院及唐山市妇幼保健院行宫颈癌手术的216例患者为研究对象,记录术前1周内最近一次中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)、C反应蛋白(CRP)、D-二聚体(D-D)、纤维蛋白原(FIB)、糖类抗原125(CA125)结果,以宫颈癌病理类型、病理分期、分化程度、有无淋巴结转移分组,采用t检验和F检验分析以上生化指标与宫颈癌临床病理特征之间的相关性。结果上述指标在不同病理类型分组中差异均无统计学意义(P>0.05);NLR、PLR、CRP、D-D、FIB、CA125在宫颈癌不同病理分期(I-III期)、有无淋巴转移的患者中差异均有统计学意义(P<0.05);NLR、D-D、FIB、CA125在不同分化程度(高、中、低)患者中比较,差异均有统计学意义(P<0.05)。结论NLR、PLR、CRP、D-D、FIB、CA125与宫颈癌临床病理特征具有一定相关性,可作为辅助临床评估宫颈癌疾病进展与预后的重要指标。

Objective To explore the relationship between inflammatory and biochemical indicators and the clinicopathological features of uterine cervical cancer,to assist in the clinical evaluation of the disease progression and prognosis of uterine cervical cancer.Methods The 216 patients who underwent uterine cervical cancer surgery from June 2018 to July 2022 in the Affiliated Hospital of North China University of Science and Technology and Tangshan Maternal and Child Health Hospital were selected object.The recent neutrophils/lymphocyte ratio(NLR),platelet/lymphocyte ratio(PLR),C-reactive protein(CRP),D-dimer(D-D),fibrinogen(FIB)and Carbohydrate antigen 125(CA125)were recorded latest time within 1 week before operation the pathological type.All be grouped according to pathological grade and stage,degree of differentiation and lymph node metastasis of cervical cancer.t-test and one-way ANOVA(F-test)were used to analyze the correlation between he above indicators and the clinicopathological characteristics of cervical cancer.Results There was no significant difference in all indicators in different pathological grade groups(P>0.05);NLR,PLR,C-reactive protein,D-D,FIB and CA125 have significant differences in different pathological stages t(I-III stages)of cervical cancer(P<0.05);NLR,D-D,FIB and CA125 were significantly different in patients with different degrees of differentiation(high,medium and low)(P<0.05);NLR,PLR,C-reactive protein,D-D,FIB and CA125 in cervical cancer patients with or without lymph node metastasis were statistically significant(P<0.05).Conclusion NLR,PLR,C-reactive protein,D-D,FIB and CA125 have a certain correlation with the clinicopathological features of cervical cancer.Laboratory indicators can become important indicators to assist clinical evaluation of the progress and prognosis of cervical cancer.