载脂蛋白E基因多态性分布与心脑血管疾病发生风险的相关性

Correlation between apolipoprotein E gene polymorphism and cardiovascular and cerebrovascular diseases

目的分析载脂蛋白E(ApoE)基因多态性分布与心脑血管疾病发生风险的相关性。方法选取佛山市中医院心、脑病科门诊及住院部的患者3561例,采用回顾性方法研究ApoE等位基因在不同年龄段以及不同性别的分布情况,并筛选出其中1999例患者作为病例组,将其分为高血压、糖尿病、脑梗死3组,与对照组的433例体检健康人进行ApoE等位基因频率分布的比较。结果在心脑血管疾病人群中,ApoE基因多态性分布占比最高的是E3等位基因及E3/E3基因型,而且在各年龄段(P=0.721)及不同性别(P=0.369)间比较,差异无统计学意义(P>0.05);在ApoE基因型分布中,E2/E3基因型在对照组的分布频率高于病例组,差异有统计学意义(P<0.05)。对照组与高血压组、糖尿病组比较差异均无统计学意义(P>0.05);与对照组比较,ApoE等位基因的分布在病例组中差异有统计学意义(P<0.01),在高血压及脑梗死组中的分布差异也有统计学意义(P<0.05),但在糖尿病组中的分布差异无统计学意义(P>0.05);病例组的组间比较差异均无统计学意义(P>0.05)。结论ApoE基因多态性分布与心脑血管疾病的发生风险有关。

Objective To analyze the correlation between the distribution of apolipoprotein E(ApoE)gene polymorphism and the risk of cardiovascular and cerebrovascular diseases.Methods A retrospective study was conducted on the distribution of ApoE gene in different age groups and genders in 3561 patients from outpatients and inpatients of cardioencephalopathy Department of our hospital.1999 patients were selected as patient group and divided into three groups:hypertension,diabetes and cerebral infarction.The frequency distribution of ApoE gene was compared with 433 healthy people in the control group.Results In the population with cardiovascular and cerebrovascular diseases,the highest percentage of the distribution frequency of ApoE gene polymorphisms was in the E3 gene subtype and E3/E3 genotype,and the difference was not statistically significant(P>0.05)when comparing between age groups(P=0.721)and different genders(P=0.369);in the distribution of the ApoE genotypes,the frequency of the distribution of E2/E3 type in the control group was higher than that in the patient group.The difference was statistically significant(P<0.05).The differences between the control group and the hypertension,diabetes mellitus groups were not statistically significant(P>0.05);compared with the control group,the differences in the distribution of ApoE genotype subtypes were statistically significant in the patient group(P<0.01),and the differences in the distribution of the hypertension and cerebral infarction groups were also statistically significant(P<0.05),but the differences in the distribution of the diabetes mellitus group were not statistically significant(P>0.05);none of the differences in between-group comparisons of the patient groups were statistically significant(P>0.05).Conclusion The distribution of ApoE gene polymorphism is associated with the risk of cardiovascular and cerebrovascular diseases.