前列腺癌体系突变及治疗研究进展

Research Progress of Prostate Cancer Somatic Mutation and Treatment

前列腺癌是目前全球最常见的男性恶性肿瘤之一,严重威胁中老年男性健康。前列腺癌患者的临床表现和疾病预后具有个体差异,低危患者病程缓慢,死亡风险较低,而中高危患者预后较差,死亡风险较高。目前研究表明,前列腺癌的临床表现与基因突变相关,而体系突变作为前列腺癌基因突变的重要组成部分,与肿瘤的发生转移相关,可作为前列腺癌患者危险分级预后预测的潜在依据。本文就前列腺癌体系突变及治疗研究进展作一综述,以期为该疾病的诊断治疗提供借鉴。

Prostate cancer,one of the most common male malignancies in the world,seriously threatens the health of middle⁃aged and elderly men.The clinical manifestations and prognosis of prostate cancer patients have individual differences.Most low⁃risk patients have a slow disease course and a low risk of death,while inter⁃mediate⁃and high⁃risk patients have a poor prognosis and a high risk of death.Current studies have shown that prostate cancer genes have complex genetic heterogeneity associated with clinical manifestations and somatic muta⁃tion is an important part of prostate cancer genome variations.With the development of high⁃throughput sequencing technology,related research is increasing.This article reviews the research progress on somatic muta⁃tions in prostate cancer and treatment to provide reference for prognosis prediction and drug treatment of the disease.