水滴模板法制备聚己内酯蜂窝状多孔膜

Fabrication of Polycaprolactone Honeycomb Porous Membrane by Breath Figure

以聚己内酯(PCL)为成膜物,分别以二氯甲烷(DCM)和四氢呋喃(THF)为溶剂,不添加任何添加剂条件下,通过水滴模板法制备PCL蜂窝状多孔膜。研究溶剂种类、环境湿度、聚合物浓度和环境温度等条件对蜂窝孔径和形貌的影响。试验结果表明:以二氯甲烷为溶剂,质量分数为2%和4%可得到规整蜂窝孔,而6%无法得到规整蜂窝孔。蜂窝孔孔径大小与环境湿度呈现一阶线性关系。通过理论推导得到2%和4%拟合直线的斜率分别为0.202和0.211,即环境湿度每增加1%,蜂窝孔孔径分别增加0.202和0.211μm,孔径的增长率分别为0.202%和0.211%。说明浓度对孔径增长率并无太大影响。环境温度为10~50℃范围内,均得到蜂窝孔结构。以四氢呋喃为溶剂,聚合物质量分数为2%,环境湿度从43%增加到91%,孔径从(7.21±2.54)μm增加到(16.83±3.45)μm。聚合物质量分数提高至4%和6%,环境湿度为43%,无法得到孔结构,随着环境湿度的增加得到部分不规整孔结构,PCL蜂窝状多孔膜有望成为理想的组织工程支架材料。

PCL honeycomb porous films were prepared via Breath Figure method using PCL as film materials,dichloromethane and tetrahydrofuran as solvent,respectively,without adding any additives.The effects of factors,such as solvent,relative humidity,polymer concentration and temperature,on the pore sizes and patterns were investigated.The results show that regular honeycomb pores can be obtained at 2%and 4%concentrations,but not at 6%concentrations,using dichloromethane as solvents.The relationship of pore size and the relative humidity is presented first order liner relationship.Moreover,the slope of straight line with a concentration of 2%and 4%is 0.202 and 0.211,respectively,which indicates that with increasing of 1%relative humidity,the pore size with concentration of 2%and 4%increases by 0.202 and 0.211 in this system.The pore size growth rates were 0.202%and 0.211%,respectively.The above indicates that the concentration has no great effect on the pore size growth rate.When the ambient temperature was 10~50℃,the honeycomb structure was obtained.With increasing of ambient humidity from 43%to 91%,the pore size of PCL was increased from(7.21±2.54)μm to(16.83±3.45)μm,using tetrahydrofuran as solvent and polymer concentration polymer was 2%.When the polymer concentration was increased to 4%and 6%and the ambient humidity was 43%,the pore structure could not be obtained.With the increase of ambient humidity,some irregular pore structures were obtained.PCL honeycomb membrane is expected to be an ideal tissue engineering scaffold material.