灵芝及其制品保肝作用研究进展

Research Progress on Hepatoprotective Effect of Ganoderma spp.and Related Products

灵芝(Ganoderma spp.)是我国传统的名贵中药材,含有灵芝多糖、灵芝三萜、甾醇等多种生物活性物质,具有良好的保肝护肝作用。分别从灵芝及其制品对不同类型肝损伤的保护和对肝纤维化及肝癌的抑制作用等方面对已有的研究进展进行综述。灵芝及其制品对酒精性、药物性、有毒物质、病毒性、缺血再灌注性等不同类型肝损伤均具有预防和治疗的作用,可以延缓肝病的发展进程,抑制星状细胞增殖,改善肝纤维化程度,抑制肝癌细胞增殖与迁移,促进肝癌细胞凋亡等。

Ganoderma spp.,a genus of fungi belonging to the family Polyporaceae,are traditional precious Chinese medicines.Ganoderma spp.contain various bioactive substances,such as Ganoderma polysaccharides,Ganoderma esters(triterpenes),steroids,and they have liver protection effects.The protective effects of Ganoderma spp.and the related products on different types of hepatic injuries,as well as their inhibitory effects on liver fibrosis and liver cancer were reviewed.Ganoderma spp.and the related products can be used to prevent and treat hepatic injuries induced by alcohol,drugs,toxic substances,viruses,and ischemia-reperfusion.They can delay the development of liver disease,inhibit the proliferation of stellate cells,improve the degree of liver fibrosis,inhibit the proliferation and migration of liver cancer cells,and promote apoptosis in liver cancer cells.