期刊文献+

1例帕妥珠单抗联合曲妥珠单抗治疗致4级腹泻的药学实践

Pharmacy practice of pertuzumab combined with trastuzumab in the treatmen t of Grade 4 diarrhea in 1 case
下载PDF
导出
摘要 目的:分析1例乳腺癌患者术后使用帕妥珠单抗注射液联合注射用曲妥珠单抗辅助治疗出现4级腹泻后的用药情况。方法:临床药师参与1例乳腺癌患者术后使用帕妥珠单抗注射液联合注射用曲妥珠单抗辅助治疗出现4级腹泻的临床治疗,协助医生制定止泻方案,并对患者进行药学监护。结果:临床药师参与后,成功控制了患者的4级腹泻。结论:临床药师通过参与乳腺癌患者术后使用帕妥珠单抗注射液联合注射用曲妥珠单抗辅助治疗所致4级腹泻的临床治疗,提供个体化用药方案,发挥了积极作用。 Objective:To analyze the use of pertuzumab injection combined with trastuzumab injection for adjuvant treatment of grade 4 diarrhea in a patient with breast cancer after surgery.Methods:Clinical pharmacists participated in the clinical treatment of grade 4 diarrhea in a breast cancer patient after surgery with pertuzumab injection combined with trastuzumab for injection,assisted doctors in developing antidiarrheal programs,and conducted pharmaceutical care for the patient.Results:With the participation of clinical pharmacists,Grade 4 diarrhea was successfully controlled.Conclusion:Clinical pharmacists have played a positive role in the clinical treatment of grade 4 diarrhea caused by postoperative pertuzumab injection combined with trastuzumab for injection,providing individualized medication plan for breast cancer patients.
作者 梁紫微 吕丹丹 LIANG Ziwei;Lv Dandan(Department of Pharmacy,Anshun People’s Hosp ital,Anshun Guizhou 561000;Department of Oncology,Anshun People’s Hosp ital,Anshun Guizhou 561000)
出处 《当代医药论丛》 2023年第14期183-186,共4页
关键词 帕妥珠单抗 曲妥珠单抗 4级腹泻 药学实践 pertuzumab Trastuzumab Grade 4 diarrhea Pharmacy practice
  • 相关文献

参考文献5

二级参考文献34

  • 1Viele CS. Overview of chemotherapy-induced diarrhea. Semin Oncol Nurs, 2003, 19:2-5.
  • 2Gibson R J, Keefe DM. Cancer chemotherapy-induced diarrhoea and constipation : mechanisms of damage and prevention strategies. Support Care Cancer, 2006, 14: 890-900.
  • 3Stringer AM, Gibson RJ, Logan RM, et al. Gastrointestinal microflora and mucins may play a critical role in the development of 5-Fluorouracil-induced gastrointestinal mucositis. Exp Biol Med (Maywood), 2009, 234: 430-441.
  • 4Stringer AM, Gibson R J, Logan RM, et al. Chemotherapy- induced diarrhea is associated with changes in the luminal environment in the DA rat. Exp Biol Med ( Maywood ), 2007, 232 : 96-106.
  • 5Benson AB 3rd, Ajani JA, Catalano RB, et al. Recommended guidelines for the treatment of cancer treatment-induced diarrhea. J Clin Oncol, 2004,22: 2918-2926.
  • 6Sartor RB. Therapeutic manipulation of the enteric microflora in inflammatory bowel diseases : antibiotics, probiotics, and prebiotics. Gastroenterology, 2004, 126: 1620-1633.
  • 7Mennigen R, Nolte K, Rijcken E, et al. Probiotic mixture VSL# 3 protects the epithelial barrier by maintaining tight junction protein expression and preventing apoptosis in a murine model of colitis. Am J Physiol Gastrointest Liver Physiol, 2009, 296: G1140 -G1149.
  • 8Caballero-Franeo C, Keller K, De Simone C, et al. The VSL# 3 probiotic formula induces mucin gene expression and secretion in colonic epithelial cells. Am J Physiol Gastrointest Liver Physiol, 2007, 292: G315-G322.
  • 9Logan RM, Stringer AM, Bowen JM, et al. The role of pro- inflammatory cytokines in cancer treatment-induced alimentary tract mucositis: pathobiology, animal models and cytotoxic drugs. Cancer Treat Rev, 2007, 33: 448-460.
  • 10Sonis ST. Mucositis as a biological process: a new hypothesis for the development of chemotherapy-induced stomatotoxicity. Oral Oncol, 1998, 34:39-43.

共引文献65

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部