基于数据挖掘的中医干预新生儿黄疸用药规律研究

Medication Rules of TCM Intervention in Neonatal Jaundice Based on Data Mining

目的:利用数据挖掘方法,分析中医干预新生儿黄疸的用药规律,为临床提供参考。方法:以“胎黄”或“新生儿黄疸”为主题词,检索中华医典(V5.0)、国家知识基础设施数据库(CNKI)(2000年1月1日至2021年8月1日),建立数据库,使用中医传承计算平台(V3.0)进行频次、关联规则和聚类分析。结果:共筛选出127首中医处方,涉及中药194味,使用频次排名前5位的中药依次为茵陈、甘草、栀子、茯苓、大黄;通过对高频药物(使用频次≥5次)的药物性味进行分析,结果显示,中医处方干预新生儿黄疸以苦、甘、辛味,寒、平、温性药,归脾、胃、肺经为主。通过对高频药物聚类分析得到3类组合,关联规则分析得出6个潜在组合药对。结论:利湿退黄为中医干预新生儿黄疸的基本法则,对高频药物聚类分析得到的6个潜在药对组合均以茵陈蒿汤为基础方,辅以补中益气,拟对中医干预新生儿黄疸的临床用药提供参考。

Objective:To analyze the medication rules of traditional Chinese medicine(TCM)intervention in neonatal jaundice by using data mining,so as to provide references for clinical practice.Methods:With“jaundice in newborns”or“neonatal jaundice”as the key words,we searched the Chinese Medical Dictionary(V5.0)and China National Knowledge Infrastructure(CNKI)for relevant articles with the time interval from January 1,2000 to August 1,2021.A library was established,and the Traditional Chinese Medicine Inheritance Computing Platform(V3.0)was used for the statistics of frequency,mining of association rules,and cluster analysis.Results:A total of 127 TCM prescriptions were screened out,involving 194 Chinese herbal medicines.The top 5 Chinese herbal medicines in use frequency were Artemisiae Scopariae Herba,Glycyrrhizae Radix et Rhizoma,Gardeniae Fructus,Poria,and Rhei Radix et Rhizoma.Furthermore,the natures and tastes of the Chinese herbal medicines with the frequency≥5 were analyzed.The results showed that the TCM prescriptions for neonatal jaundice mainly used bitter,sweet,or pungent herbs with cold,plain or warm nature,and these herbs mainly had tropism to the spleen,stomach,and lung meridians.The cluster analysis of high-frequency drugs yielded three clusters,and the association rule analysis predicted six potential herb pairs.Conclusion:Excreting dampness and eliminating jaundice is the basic rule of TCM in the intervention of neonatal jaundice.The six potential herb pairs obtained by cluster analysis of high-frequency drugs are based on Yinchenhao Decoction,supplemented by the prescriptions for tonifying middle and replenishing qi.The findings are expected to provide references for the clinical medication of TCM intervention in neonatal jaundice.