依达拉奉右莰醇注射液对急性大动脉粥样硬化型脑梗死患者炎症反应及不良反应的影响

Effects of Edaravone Dextran Injection on Inflammatory Response and Adverse Reactions in Patients with Acute Large Artery Atherosclerotic Cerebral Infarction

目的探讨依达拉奉右莰醇注射液用于急性大动脉粥样硬化型脑梗死患者治疗中的临床效果。方法选取2021年8月—2022年8月聊城市肿瘤医院收治的92例急性大动脉粥样硬化型脑梗死患者为研究对象,基于“简单随机化方法”规范化分组处理,划分为对照组(实行脑梗死常规治疗)与观察组(实行脑梗死常规治疗+依达拉奉右莰醇注射液治疗),每组46例;观察对比两组临床疗效及不良反应发生率、神经功能缺损及预后情况、血清炎症因子和氧化应激水平。结果观察组治疗总有效率为95.65%,显著高于对照组的82.61%,差异有统计学意义(χ^(2)=4.039,P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。治疗3个月后,观察组NIHSS、mRS评分较对照组更低,差异有统计学意义(P<0.05)。治疗后,两组hs-CRP、MMP-9、MDA水平均下降,SOD水平均升高,其中观察组更优,差异有统计学意义(P<0.05)。结论急性大动脉粥样硬化型脑梗死患者应用依达拉奉右莰醇注射液,可抑制机体炎症反应及氧化应激反应,改善脑部血供,促进神经功能恢复,提高预后,其治疗安全性及有效性兼顾。

Objective To investigate the clinical effects of edaravone dextran injection in the treatment of patients with acute large artery atherosclerotic cerebral infarction.Methods 92 patients with acute cerebral infarction of Atherosclerosis type admitted to Liaocheng Cancer Hospital from August 2021 to August 2022 were selected as the research objects.Based on the standardized grouping treatment of"simple randomization method",they were divided into a control group(routine treatment of cerebral infarction)and an observation group(routine treatment of cerebral infarction+Edaravone and right camphor injection),with 46 cases in each group.The clinical efficacy and rate of adverse reactions,neurological deficits and prognosis,serum inflammatory factors and oxidative stress levels were observed and compared between the two groups.Results The total effective rate of treatment in the observation group was 95.65%,which was statistically significantly higher than that of 82.61%in the control group,and the difference was statistically significant(χ^(2)=4.039,P<0.05).There was no statistically significant difference in the rate of adverse reactions between the two groups(P>0.05).After 3 months of treatment,the NIHSS and mRS scores in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).After treatment,hs-CRP,MMP-9,and MDA levels decreased and SOD levels increased in both groups,with the observation group being superior,and the difference was statistically significant(P<0.05).Conclusion The application of edaravone dextran injection in patients with acute large atherosclerotic cerebral infarction can inhibit the inflammatory response and oxidative stress,improve cerebral blood supply,promote the recovery of neurological function and improve the prognosis,and its therapeutic safety and effectiveness are balanced.