上消化道出血患者应用生长抑素联合泮托拉唑治疗的临床效果

Clinical Effects of Applying Growth Inhibitors Combined with Pantopra⁃zole in Patients with Upper Gastrointestinal Bleeding

目的探讨上消化道出血(upper gastrointestinal bleeding,UGIB)患者应用生长抑素联合泮托拉唑治疗的临床效果。方法选取2021年6月—2022年12月丰县人民医院收治的84例UGIB患者为研究对象,以随机抽签法将其分为两组,各42例。对照组施以泮托拉唑治疗,观察组在此基础上采用生长抑素治疗。比较两组临床疗效、输血量、止血和住院时间、治疗前后BUN、HGB、凝血功能指标水平。结果观察组的总有效率95.24%高于对照组的80.95%,差异有统计学意义(χ^(2)=4.086,P<0.05)。观察组输血量、止血时间、住院时间均优于对照组,差异有统计学意义(P<0.05)。治疗后,两组BUN、HGB水平均优于治疗前,且观察组优于对照组,差异有统计学意义(P<0.05)。治疗后,两组APTT、PT、D-D水平下降,FIB水平上升,且观察组APTT、PT、D-D水平低于对照组,FIB水平高于对照组,差异有统计学意义(P<0.05)。结论生长抑素联合泮托拉唑应用于UGIB患者的治疗中,临床效果显著,有利于减少输血量,缩短止血和住院时间,同时也能有效改善患者BUN、HGB和凝血功能指标水平。

Objective To investigate the clinical effect of applying growth inhibitors combined with pantoprazole in patients with upper gastrointestinal bleeding(UGIB).Methods 84 UGIB patients admitted to Fengxian People's Hospital from June 2021 to December 2022 were selected as the research subjects and randomly divided into two groups,with 42 patients in each group.The control group was treated with Pantoprazole,and the observation group was treated with somatostatin on this basis.Compared the clinical efficacy,blood transfusion volume,hemostasis,hospital stay,BUN,HGB,and coagulation function indicators before and after treatment between the two groups.Results The total effective rate of 95.24%in the observation group was higher than 80.95%in the control group,the difference was statistically significant(χ^(2)=4.086,P<0.05).The observation group had better blood transfusion volume,hemostasis time,and hospitalization time than the control group,the difference was statistically significant(P<0.05).After treatment,the BUN and HGB levels in both groups were better than before treatment,and the observation group was better than the control group,the difference was statistically significant(P<0.05).After treatment,the levels of APTT,PT,D-D decreased and FIB increased in the two groups,and the levels of APTT,PT,D-D in the observation group were lower than those in the control group,while FIB levels was higher than that in the control group,the difference was statistically significant(P<0.05).Conclusion Somatostatin combined with Pantoprazole in the treatment of UGIB patients has significant clinical effect,which is conducive to reducing blood transfusion,shortening hemostasis and hospital stay,and can also effectively improve the BUN,HGB and coagulation function index levels of patients.