肠安颗粒治疗腹泻型肠易激综合征患者的疗效研究

Study on the efficacy of Chang’an granules in the treatment of patients with diarrheal irritable bowel syndrome

目的 :分析肠安颗粒对腹泻型肠易激综合征(IBS-D)的疗效。方法 :将60例IBS-D(肝郁脾虚证)患者随机分为对照组(n=30)和观察组(n=30),对照组给予匹维溴铵片+双歧杆菌乳杆菌三联活菌片,观察组在此基础上加用肠安颗粒,观察两组疗效、病情改善情况、内脏敏感性、直肠动力和不良反应情况。结果 :治疗后,观察组治疗总有效率高于对照组,IBS-SSS评分、IBS-QOL评分、内脏敏感指数(VSI)、肛管静息压优于对照组(均P <0.05)。两组患者均未出现明显不良反应。结论 :在西医常规治疗基础上采用肠安颗粒治疗IBS-D可显著提高治疗效果,提高患者直肠动力和生活质量。

Objective:To analyze the efficacy of Chang’an granules on diarrheal irritable bowel syndrome(IBS-D).Methods:Sixty patients with IBS-D(liver-depression and spleen-deficiency evidence)were randomly divided into a control group(n=30)and an observation group(n=30).Both groups were given pivetonium bromide tablets+Lactobacillus bifidum triptans tablets,and the observation group was additionally given Chang’an granules.The efficacy,improvement of condition,visceral sensitivity,rectal dynamics and adverse reactions in the two groups were observed.Results:After treatment,the total effective rate of treatment was higher and the IBS-SSS score,IBS-QOL score,visceral sensitivity index(VSI)and anal canal resting pressure were better in the observation group than the control group(all P<0.05).No significant adverse effects were observed in either group.Conclusion:Chang’an granules plus the conventional Western medicines for the treatment of IBS-D can significantly improve the therapeutic effect and the quality of life of patients and enhance rectal dynamics.