生酮饮食干预多囊卵巢综合征中国专家共识(2022年修订版)

Chinese expert consensus of ketogenic diet intervention for polycystic ovary syndrome(2022 revision)

多囊卵巢综合征(PCOS)是育龄期女性最常见的妇科内分泌疾病之一。生酮饮食(KD)是一种以低碳水化合物、高脂肪、适量蛋白质为特点的饮食结构。2019年专家组组织了妇科专家和营养专家共同制定并发布了《生酮饮食干预多囊卵巢综合征中国专家共识(2018年版)》。鉴于近5年KD治疗在安全性和应用范围方面出现了大量新的临床数据,专家组决定对《生酮饮食干预多囊卵巢综合征中国专家共识(2018年版)》进行修订和数据更新。主要更新内容有:①更新中国PCOS患病率研究数据;②增加PCOS中的代谢综合征与饮食干预临床证据;③增加KD改善PCOS的循证证据及中国临床研究证据;④增加KD对与PCOS相关代谢综合征影响的循证医学证据;⑤提供短期和长期KD有效性和安全性证据;⑥增加低能量生酮饮食(LCKD)在PCOS中的应用及安全性证据;⑦增加PCOS治疗常用药物联合KD干预效果的证据;⑧完善KD干预PCOS的适应证、禁忌证、不良反应及对策;⑨完善KD中食物种类的选择及操作方法建议。

Polycystic ovary syndrome(PCOS)is one of the most common gynecological endocrine diseases in women of childbearing age.Ketogenic diet(KD)is a dietary structure that is characterized by low carbohydrate,high fat and moderate protein.In 2019,the expert group organized a team consisted of gynecotokologists and nutritionists to jointly formulate and release the Chinese Expert Consensus on Ketogenic Diet as Medical Prescription in Polycystic Ovary Syndrome(2018).Since a numbeRof new clinical data on the safety and application of KD therapy have been obtained in the past five years,the expert group decided to revise and update Chinese Expert Consensus on Ketogenic Diet as Medical Prescription in Polycystic Ovary Syndrome(2018).The main updates are as follows:①to update the epidemiological data of PCOS in China;②to increase the clinical evidence of metabolic syndrome and dietary intervention in PCOS patients;③to add evidence-based and new clinical trial evidence of KD in improving PCOS;④to increase the evidence based on evidence-based medicine in impacts of KD on PCOS-associated metabolic syndrome;⑤to provide evidence in short-term and long-term efficacy and safety of KD;⑥to increase the application and safety evidence of low calorie ketogenic diet(LCKD)in PCOS;⑦to increase the evidence of effects by commonly used drugs combined with KD intervention foRPCOS;⑧to improve the indications,contraindications,adverse reactions and countermeasures during KD intervention in PCOS;⑨to improve the selection of food types and provide suggestions on operation methods.