锌制剂对儿童轮状病毒性肠炎患儿心肌酶及心肌肌钙蛋白Ⅰ的改善作用

Role of zinc preparations in improving myocardial enzymes and cardiac troponin I of children with pediatric rotavirus enteritis

目的探讨锌制剂对儿童轮状病毒性肠炎患儿心肌酶及心肌肌钙蛋白I的改善作用。方法将150例儿童轮状病毒性肠炎患儿按照组间基本特征匹配原则分为对照组和观察组,每组75例。对照组给予常规治疗,观察组给予常规治疗联合锌制剂(葡萄糖酸锌)治疗,2组均治疗7 d。比较2组患儿的症状改善时间、心肌酶及心肌肌钙蛋白I水平、以及临床疗效。结果观察组止泻、止吐、退热的时间均短于对照组,差异有统计学意义(P<0.05)。2组治疗后的肌酸激酶、肌酸激酶同工酶、乳酸脱氢酶均较治疗前降低,且观察组上述指标均低于对照组,差异有统计学意义(P<0.05)。2组治疗后的心肌肌钙蛋白I水平均较治疗前降低,且观察组心肌肌钙蛋白I水平低于对照组,差异有统计学意义(P<0.05)。观察组总有效率为97.33%,高于对照组的85.33%,差异有统计学意义(P<0.05)。结论锌制剂治疗儿童轮状病毒性肠炎的效果较好,可快速改善患儿症状及心肌酶、心肌肌钙蛋白I水平。

Objective To explore the role of zinc preparations in improving myocardial enzymes and cardiac troponin I of children with pediatric rotavirus enteritis.Methods A total of 150 children with pediatric rotavirus enteritis were divided into control group and observation group according to the matching principles of basic between-group characteristics,with 75 cases in each group.The control group was treated with routine treatment,while the observation group was treated with routine treatment and zinc preparations(zinc gluconate),and both groups were treated for 7 days.The symptom improvement time,myocardial enzyme and cardiac troponin I levels,and clinical efficacy were compared between two groups.Results The time for relieving diarrhea,vomiting and fever in the observation group was significantly shorter than that in the control group(P<0.05).After treatment,the levels of creatine kinase,creatine kinase isozyme and lactate dehydrogenase in both groups decreased significantly,and these indexes in the observation group were significantly lower than those in the control group(P<0.05).After treatment,the level of cardiac troponin I in both groups decreased significantly,and the cardiac troponin I level in the observation group was significantly lower than that in the control group(P<0.05).The total effective rate was 97.33%in the observation group,which was significantly higher than 85.33%in the control group(P<0.05).Conclusion Zinc preparations are effective in the treatment of children with pediatric rotavirus enteritis,which can quickly improve the symptoms and the levels of myocardial enzymes and cardiac protein troponin I.