羟考酮用于产科镇痛的研究进展

Research Progress of Oxycodone in Obstetric Analgesia

羟考酮为阿片受体纯激动剂,通过激动μ、κ双阿片受体产生镇痛作用,具有口服生物利用度高、镇痛效果好、不良反应少等优点,在临床上被广泛用于中度到重度疼痛的治疗中。目前关于羟考酮对胎儿影响的相关临床研究较少,本文通过查阅文献总结羟考酮的药理学、产科镇痛等方面的研究进展,综述其安全性和有效性。

Oxycodone is a pure agonist opioid receptor.It can produce analgesic effect from activatingμ、κdual opioid receptors.They have the advantages of high oral bioavailability,good analgesic effect and small adverse reactions.They are widely used in the treatment of moderate to severe pain in clinic.At present,there are few clinical studies on the effect of oxycodone on fetus.In this research,our aim is to summarize the progress of oxycodone in pharmacology and obstetric analgesia,and explore its safety and effectiveness by consulting the literature.