基于WOS数据库的腹部实体器官移植术后耐药菌感染文献计量和可视化分析

Bibliometrics and Visualization Analysis of Antibiotic Resistant Bacteria Infection after Abdominal Solid Organ Transplantation Based on WOS Database

目的对腹部实体器官移植(SOT)术后耐药菌感染的文献进行文献计量和可视化分析,为临床确定当前研究热点和未来开展相关研究提供参考。方法检索WOS数据库,搜索关键词“carbapenem-resistant enterobacteriaceae”“carbapenem-resistant klebsiella pneumoniae”“multidrug-resistant”“solid organ transplant”等。使用CiteSpace软件检测引文突现,用VOS viewer作关键词共现,分析研究现状和热点。文献计量学方法分析腹部SOT耐药菌文献年发文量、发文国家、作者、机构。结果共检索到文献710篇,51个关键词出现6次以上,聚类分析主要集中在分子流行病学、碳青霉烯耐药肠杆菌、感染危险因素及抗生素治疗、免疫抑制剂遗传药理学和手术部位感染主题。发文量美国最多其次是中国。耐药菌分子流行病学和供者来源的感染是现在的研究热点。结论多耐药肠杆菌感染的分子流行病学、供者来源感染是研究的热点,可能会指导未来的研究方向,这也将有助于临床更好地了解腹部SOT耐药菌感染并实施有效的抗生素管理。

Objective Bibliometric and visualization analysis of literature related to antibiotic-resistant bacterial infection after abdominal solid organ transplant(SOT)was conducted to provide references for identifying clinical research hotspots and related research in the future.Methods The“Web of Science”(WOS)database was searched with keywords such as“carbapenem-resistant Enterobacteriaceae”,“carbapenem-resistant Klebsiella pneumonia”,“multidrug-resistant”and“solid organ transplant”.CiteSpace software was used to detect citation prominences,and VOS viewer was used to cluster keywords to analyze research status and development trends visually.The bibliometrics method was applied to analyze the number of articles related to abdominal solid organ transplant published per year,countries,authors,and institutions.Results A total of 710 articles on antibiotic-resistant bacterial infection after solid organ transplant was finally included in the bibliometric analysis.Fifty-one keywords occurred more than six times,and five related theme clusters were identified,mainly focusing on molecular epidemiology,carbapenem-resistant Enterobacteriaceae,risk factors for infection and antibiotic treatment,immunosuppressant pharmacogenetics,and surgical site infection.The United States has made the greatest contribution,followed by China.Molecular epidemiology of antibiotic-resistant bacterial infection and donor-derived infection were emerging hot topics that would probably attract future research interest.Conclusion Hot topics such as molecular epidemiology of multi-drug resistant Enterobacteriaceae infection and donor-derived infection would not only direct future research but also help us better understand SOT antibiotic-resistant bacterial infection thus implementing the effective antibiotic stewardship program.