LL-全自动血球计数仪、特定蛋白免疫分析仪与荧光免疫定量分析仪检验白细胞计数、C-反应蛋白、降钙素原和白介素-6在炎症中的诊断价值分析

Analysis of Diagnostic Value of White Blood Cell Count,C-Reactive Protein,Procalcitonin and Interleukin-6 in Inflammation by Automatic Blood Cell Counter and Electrochemiluminescence Immunoassay Analyzer

目的:探析全自动血球计数仪与电化学发光免疫分析仪分别检测白细胞(WBC)计数、C-反应蛋白以及降钙素原、白细胞介素-6对炎症的诊断价值。方法:纳入2020年11月~2021年10月本院接诊的64例炎症患者作为研究对象,结合临床诊断,按其白细胞检测结果分为轻症组(36例,白细胞为9.5×10^(9)~15×10^(9)/L)、重症组(28例,白细胞>15×10^(9)/L),另选择同一时间段至本院例行体检的38例健康志愿者列为对照组,采用全自动血球计数仪检测白细胞、全自动特定蛋白免疫分析仪检测C-反应蛋白指标,采用全自动荧光免疫定量分析仪检测降钙素原、白细胞介素-6水平,对比三组研究对象上述指标间的差异及炎症检出情况。结果:重症组患者的C-反应蛋白、降钙素原、白细胞介素-6水平均高于轻症组和对照组,差异具有统计学意义(P<0.05);采用全自动血球计数仪及电化学发光免疫分析仪检测相关指标后炎症轻症组患者的检出率为91.67%,敏感度为92.31%、特异度为91.67%;重症组患者的检出率为92.86%,敏感度为93.33%、特异度为92.86%,差异无统计学意义(P>0.05)。结论:采用全自动血球计数仪、全自动特定蛋白免疫分析仪及全自动荧光免疫定量分析仪对不同白细胞炎症患者的检出率较高,对指导患者的临床诊断及治疗均有着重要意义。

Objective:Analyze the diagnostic value of WBC,CRP,PCT and IL-6 with automatic blood cell counter and electrochemiluminescence immunoassay.Methods:Select 64 patients with inflammation admitted to our hospital from November 2020 to October 2021 as the research objects,and divide them into mild group(36 cases,WBC is 9.5×10^(9)~15×10^(9)/L)and severe group(28 cases,WBC>15×10^(9)/L),another 38 healthy volunteers were selected as the control group,using automatic blood cell counter to detect WBC,automatic specific protein immunoassay to detect CRP indicators,and detection of pro calcitonin and interleukin 6 levels by automatic fluorescence immunoassay,and compares the differences between the above indicators and the detection of inflammation.Results:The levels of CRP,PCT and IL-6 in the severe group were higher than those in the mild group and the control group(P<0.05);The detection rate of inflammation in the mild group was 91.67%,the sensitivity was 92.31%,and the specificity was 91.67%;The detection rate of severe patients was 92.86%,the sensitivity was 93.33%,and the specificity was 92.86%(P>0.05).Conclusion:The automatic blood cell counter,the automatic specific protein immunoassay analyzer and the automatic fluorescent immunoquantitative analyzer are of great significance for guiding the clinical diagnosis and treatment of patients with different WBC inflammations.