替罗非班对脑血管支架置入后患者血栓形成的影响

Effect of tirofiban on thrombosis in patients with cerebralvascular stent implantation

目的探究替罗非班对脑血管支架置入后患者血栓形成的影响。方法选取贵港市人民医院神经内科2020年2月~2022年10月纳入的106例脑血管支架置入后患者,采用随机分组方法分为对照组和观察组,各53例,其中对照组采用常规方法治疗,观察组在对照组的基础上采用替罗非班治疗。评估两组临床疗效、血清炎症因子水平、生活质量、并发症和满意度。结果观察组临床总有效率为98.11%,高于对照组的86.79%(P<0.05);治疗前,两组患者血清白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)水平差异均无统计学意义(P>0.05),治疗后,两组血清IL-6、TNF-α、hs-CRP水平均降低,且观察组低于对照组(P<0.05);治疗前,两组患者生活质量量表(SF-36)评分差异无统计学意义(P>0.05),治疗后,两组SF-36评分均上升,且观察组高于对照组(P<0.05);观察组患者肺栓塞、静脉血栓、心力衰竭等并发症的发生率为3.77%,低于对照组的15.09%(P<0.05);观察组患者满意度为98.11%,显著高于对照组的84.91%(P<0.05)。结论替罗非班应用于脑血管支架置入后患者疗效显著,可有效降低血清炎症因子水平,改善生活质量,减少并发症的发生,提高患者的满意度。

Objective To explore the effect of tirofiban on thrombosis in patients with cerebralvascular stent implantation.Methods A total of 106 patients with cerebrovascular stent implantation who were enrolled in the department of neurology of Guigang People's Hospital from February 2020 to October 2022 were randomly divided into control group and observation group,with 53 patients in each group.The control group was treated with conventional methods,and the observation group was treated with tirofiban on the basis of the control group.The clinical efficacy,serum inflammatory factor levels,quality of life,complications and satisfaction of the two groups were evaluated.Results The total effective rate of the observation group was 98.11%,which was higher than that of the control group(86.79%)(P<0.05).Before treatment,there were no statistically significant differences in serum levels of interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and hypersensitive C-reactive protein(hs-CRP)between 2 groups(P>0.05).After treatment,serum levels of IL-6,TNF-αand hs-CRP in two groups were decreased,and observation group was lower than control group(P<0.05).Before treatment,there was no statistically significant difference in the score of quality of Life scale(SF-36)between two groups(P>0.05).After treatment,the score of SF-36 in two groups was increased,and the observation group was higher than the control group(P<0.05).The incidence of pulmonary embolism,venous thrombosis,heart failure and other complications in observation group was 3.77%,which was lower than that in control group(15.09%)(P<0.05).The satisfaction of the observation group was 98.11%,significantly higher than that of the control group(84.91%)(P<0.05).Conclusion The application of tirofiban in patients with cerebrovascular stent implantation has significant curative effect,which can effectively reduce the level of serum inflammatory factors,improve the quality of life,reduce the formation of thrombosis,and improve the satisfaction of patients.