复方樟柳碱联合五苓逍遥散治疗中心性浆液性脉络膜视网膜病变的临床效果评价

Clinical evaluation of compound anisodine combined with wuling xiaoyao powder in the treatment of central serous chorioretinopathy

目的:分析复方樟柳碱联合五苓逍遥散治疗中心性浆液性脉络膜视网膜病变(CSC)的疗效和安全性。方法:选择2021年9月—2022年8月收治的CSC患者共62例(70眼)。以患者就诊时视力作为控制因素,采用随机数字表法,将患者随机分为观察组31例(36眼)和对照组31例(34眼)。对照组予以2 mL复方樟柳碱颞浅动脉注射治疗,每日1次。观察组在此基础上,予以口服五苓逍遥散,每日2次。两组均治疗3个月。治疗3个月后,比较两组治疗总有效率,并记录治疗期间不良反应发生率以及治疗前后的视力和视野平均缺损情况。结果:观察组治疗总有效率为86.11%,高于对照组的69.44%(P<0.05)。两组治疗后的视力和视野平均缺损均较治疗前改善(P<0.05)。观察组治疗后的视力和视野平均缺损均好于对照组(P<0.05)。观察组治疗期间不良反应率与对照组比较差异无统计学意义(P>0.05)。结论:在复方樟柳碱治疗的基础上,予以口服五苓逍遥散治疗中心性浆液性脉络膜视网膜病变,可以取得更好的疗效,且安全性较高。

Objective:To evaluate the efficacy and safety of compound anisodine combined with wuling xiaoyao powder in the treatment of central serous chorioretinopathy(CSC).Methods:All 62 patients(70 eyes)with CSC from September 2021 to August 2022 in hospital were selected as subjects.The patients were randomly divided into 31 patients(36 eyes)in the observation group and 31 patients(34 eyes)in the control group by using the random number table method,taking the vision of patients at the time of treatment as the control factor.In the control group,2 mL compound anisodine was injected into the superficial temporal artery once a day.On this basis,the observation group was given wuling xiaoyao powder orally twice a day.Both groups were treated for 3 months.After 3 months of treatment,the total effective rate of the two groups was compared,and the incidence of adverse reactions during the treatment and the average visual acuity and visual field defects before and after treatment were recorded.Results:The total effective rate of the observation group was 86.11%,which was higher than that of the control group(69.44%)(P<0.05).The average visual acuity and visual field defect of the two groups after treatment were improved compared with those before treatment(P<0.05).The mean visual acuity and visual field defects in the observation group after treatment were better than those in the control group(P<0.05).There was no significant difference in adverse reaction rate between the two groups(P>0.05).Conclusion:On the basis of compound anisodine treatment,oral administration of wuling xiaoyao powder in the treatment of central serous chorioretinopathy can achieve better efficacy and higher safety.