自拟菖蒲益智汤联合埋针疗法在中风后轻度认知障碍患者中的应用效果

Application effect of self-made Changpu Yizhi Decoction combined with embedding needle therapy on the treatment of mild cognitive impairment after stroke

目的探讨自拟菖蒲益智汤联合埋针疗法治疗中风后轻度认知障碍(MCI)的临床效果。方法选取2020年1月至2022年9月于山东省乳山市中医院治疗的80例中风后MCI患者作为研究对象,按照随机数字表法将其分为对照组(40例)和观察组(40例)。对照组采用艾地苯醌片+常规内科治疗,观察组采用艾地苯醌片+常规内科+自拟菖蒲益智汤联合埋针疗法治疗。比较两组患者的临床疗效、中医证候积分、认知功能、生活质量及不良反应。结果观察组临床总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者中医证候积分、简易精神状态检查量表(MMSE)、脑卒中影响量表(SIS)评分比较,差异无统计学意义(P>0.05);治疗后,两组患者各中医证候积分及总分低于本组治疗前,且观察组各中医证候积分及总分低于对照组,两组患者MMSE、SIS评分高于本组治疗前,且观察组MMSE、SIS评分高于对照组,差异有统计学意义(P<0.05)。两组患者未见明显不良反应。结论中风后MCI患者应用自拟菖蒲益智汤联合埋针疗法治疗可改善认知功能,缓解临床症状,提升患者生活质量,效果显著,安全性好,值得推广。

Objective To explore the clinical effect of self-made Changpu Yizhi Decoction combined with embedding needle therapy in the treatment of mild cognitive impairment(MCI)after stroke.Methods A total of 80 patients with MCI after stroke treated in Rushan Traditional Chinese Medicine Hospital from January 2020 to September 2022 were selected as the study subjects,and they were divided into control group(40 cases)and observation group(40 cases)according to the random number table method.The patients in the control group were treated with Adibenzoquinone Tablets+conventional medicine,while the patients in the observation group were treated with Adibenzoquinone Tablets+conventional medicine+self-made Changpu Yizhi Decoction combined with embedding needle therapy.The clinical efficacy,traditional Chinese medicine syndrome score,cognitive function,quality of life and adverse reactions of the two groups were compared.Results The total clinical effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).There were no statistically significant differences between the two groups before treatment in the traditional Chinese medicine syndromes scores,mini-mental state examination(MMSE)and stroke impact scale(SIS)scores(P>0.05).After treatment,the scores and total scores of traditional Chinese medicine syndrome in the two groups were lower than those before treatment,and the scores and total scores of traditional Chinese medicine syndrome in the observation group were lower than those in the control group,and the scores of MMSE and SIS in the two groups were higher than those before treatment,and the scores of MMSE and SIS in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).There were no obvious adverse reactions in the two groups.Conclusion The treatment of MCI after stroke patients with self-made Changpu Yizhi Decoction combined with embedding needle therapy can improve cognitive function,relieve clinical symptoms,and improve the quality of life of patients,with significant effect and good safety,which is worthy of promotion.