肠道菌群代谢物与炎症性肠病关系的研究进展

Relationship between intestinal flora metabolites and inflammatory bowel disease:research progress

人类肠道菌群是一个复杂的共生微生物系统,长期定植于人类的胃肠道中,通过发酵产生大量的代谢产物,如短链脂肪酸、色氨酸及吲哚衍生物、胆汁酸和三磷酸腺苷等,对人体产生局部和全身的作用,并与炎症性肠病(inflammatory bowel disease,IBD)的发生发展密切相关。近年来,基于高通量基因测序技术的肠道微生物组学和代谢组学已成为新的研究热点,通过研究微生物群的小分子代谢物,发现微生物、代谢物和宿主三者间相互作用的潜在机制,而肠道菌群代谢物与IBD密切相关,这为预防和治疗IBD提供了新的策略。本文就近年来肠道菌群主要代谢物与IBD之间的关系及其潜在机制的重要研究成果进行综述。

Human intestinal flora is a complex symbiotic system,which long colonizes the human gastrointestinal tract and produces a large number of metabolites through fermentation,such as short chain fatty acids,tryptophan and indole derivatives,bile acids and adenosine triphosphate.The metabolites produce local and systemic effects on the human body and are closely related to the occurrence and development of inflammatory bowel disease(IBD).In recent years,gut microbiome and metabolomics based on high-throughput gene sequencing technology have become a new research focus,and has discovered the potential mechanism of microbiome-metabolite-host interaction by studying the small molecular metabolites of microbial communities.Metabolites from gut flora have particularly strong association with IBD,which provide potential strategies for the prevention and treatment of IBD.In this review,we summarize the important results of research on the relationship between main metabolites of gut microbiota and IBD and potential mechanism in recent years.