柴油机尾气生物有害效应的表观遗传调控研究进展

Research progress in epigenetic toxicity of diesel exhausts

柴油机尾气(DE)成分复杂,所含的颗粒物可较长时间悬浮在空气中,进入机体致多器官损伤。表观遗传调控是不涉及DNA序列改变的转录后调控改变,已有多项证据表明DE可通过表观遗传学的变化影响多器官多系统的正常生理功能,从而调控多种疾病的发生发展。本文综述了DNA甲基化和非编码RNA在DE生物有害效应中的研究进展,为DE的安全性评价、健康风险评估以及管理提供参考依据。

Diesel exhaust(DE)can enter the organism body and cause multiple organ damage.DE contains particles that can be suspended in the air for a long time.Epigenetic regulation is a post transcriptional regulation change that does not involve DNA sequence changes.Many evidences showed that DE can affect the normal physiological functions of multiple organs and systems through epigenetic changes,thus regulating the occurrence and development of multiple diseases.This paper reviewed the research progress of DNA methylation and non-coding RNA in the biological harmful effects of DE.This will provide a basis for the safety evaluation,health risk assessment,and management of DE.