柴油机尾气颗粒对哮喘的作用及其机制的研究进展

Research progress on effect and mechanism of diesel exhaust particles on asthma

作为交通相关空气污染的来源,柴油机尾气颗粒(DPM)能够引起多种肺部相关疾病,但尚未见DPM与哮喘发生和进展关系的系统回顾。本文围绕DPM与哮喘的关系、DPM对哮喘气道炎症和重构的作用及机制进行综述,阐明DPM暴露可通过氧化应激、免疫调控及调节肺肠微生态等途径参与气道炎症和重构,从而促进哮喘的发生和进展。

As a source of traffic-related air pollution,diesel particulate matter(DPM)associate with a variety of lung-related diseases,but there is no systematic review of the relationship between DPM and the development and progression of asthma.This article reviewed the relationship between DPM and asthma,the effect and mechanism of DPM on airway inflammation and remodeling in asthma,and illustrated that DPM exposure may participate in airway inflammation and remodeling through oxidative stress,immune regulation and regulation of lung and intestinal microecology,so as to promote the development and progression of asthma.