N^(6)-腺苷酸甲基化修饰与细胞转化关系及其机制的研究进展

Research progress on relationship between N^(6)-adenylate methylation modification and cell transformation and associated mechanism

N^(6)-腺苷酸甲基化(m6A)修饰作为可逆和动态的表观遗传标记,是真核生物中最普遍的mRNA修饰。本文简略介绍了m6A可在转录后影响RNA的剪接、稳定性和翻译,进而参与多种信号通路、生物学和病理过程,调节细胞增殖、凋亡、上皮间充质转化(EMT)进程、肿瘤侵袭和转移。并且根据目前研究显示,认为m6A的甲基化转移酶(writers)大多具有促进EMT和肿瘤发生发展的作用,阅读蛋白(readers)和去甲基化酶(erasers)在不同的研究对象中既有促进也有抑制EMT的功能。在这篇综述中,我们总结归纳了m6A修饰的机制及其在细胞转化中发挥的功能的最新进展,为疾病治疗指明方向。

As a reversible and dynamic epigenetic marker,N^(6)-adenylate methylation(m6A)modification is the most common mRNA modification in eukaryotes.This paper briefly described how m6A can influence RNA splicing,stability,and translation after transcription,and then participate in a variety of signaling pathways and biological and pathological processes,regulating cell proliferation,apoptosis,epithelial mesenchymal transformation(EMT)processes,and tumor invasion and metastasis.In addition,according to current studies,m6A methyltransferases(writers)are believed to promote EMT and tumor development,and readers and erasers both promote and inhibit EMT in different research objects.In this review,we summarized the mechanism of m6A modification and its role in cell transformation,and pointed out the direction of disease treatment.