慢性心力衰竭中医证型与胱抑素C、糖类抗原125的相关性研究

Correlation between different TCM syndrome types with Cys-C and CA125 in chronic heart failure

目的研究探讨慢性心力衰竭不同中医证型与胱抑素C(Cys-C)、糖类抗原125(CA125)的相关性。方法选取2018年1月至2020年12月山东淄博市中医医院收治的105例慢性心力衰竭患者作为研究对象,另选取同时期在山东淄博市中医医院体检的健康人员50例作为对照组。首先对105例慢性心力衰竭患者的中医证型情况进行判定,然后检测2组的Cys-C及CA125水平情况,采用Spearman相关系数模型分析Cys-C与CA125之间的相关性,采用Logistic回归分析中医证型与Cys-C、CA125之间的相关性。结果105例慢性心力衰竭患者中气虚血瘀证患者最多,共24例,其次是气阴两亏证20例、心肺气虚证17例、心肾阳虚证15例、痰饮阻肺证14例、阳虚水泛证10例、阴竭阳脱证5例。观察组各中医证型患者Cys-C水平均明显高于对照组,比较差异均有统计学意义(P<0.05)。观察组各中医证型组间比较,阴竭阳脱证患者Cys-C水平明显高于其他中医证型患者,比较差异有统计学意义(P<0.05)。与对照组比较,观察组各中医证型患者CA125水平均明显高于对照组,比较差异均有统计学意义(P<0.05)。观察组各中医证型组间比较,阴竭阳脱证患者CA125水平明显高于其他中医证型患者,比较差异有统计学意义(P<0.05)。慢性心力衰竭患者Cys-C与CA125之间经Spearman相关系数模型分析显示,Cys-C与CA12之间呈正相关(r=0.602,P=0.001)。慢性心力衰竭患者不同中医证型与Cys-C、CA125之间通过Logistic回归分析显示,不同中医证型与Cys-C、CA125水平之间均存在相关性(均P<0.05)。结论慢性心力衰竭患者血清Cys-C、CA125水平普遍升高,且与慢性心力衰竭的中医证型存在相关性,可作为慢性心力衰竭证型判定的指标。

Objective To analyze the correlation between different traditional Chinese medicine(TCM)syndrome with Cystatin(Cys-C)and carbohydrate antigen 125(CA125)in chronic heart failure(CHF).Methods From January 2018 to December 2020,a total of 105 CHF patients(study group)and 50 healthy physical examination people(control group)in Zibo Hospital of traditional Chinese Medicine were enrolled.The TCM syndromes of 105 CHF patients were determined,the levels of Cys-C and CA125 in the two groups were detected.Spearman correlation coefficient test was used to analyze the correlation between Cys-C and CA125 in the two groups.Logistic regression analysis was performed to analyze the correlation between TCM syndrome and Cys-C,CA125.Results Among the 105 CHF patients,there were 24 cases of qi deficiency and blood stasis syndrome,followed by 20 cases of qi-yin deficiency syndrome,17 cases of heart-lung qi deficiency,15 cases of heart-kidney yang deficiency,14 cases of phlegm obstructing lung,10 cases of hydroretention with asthenic yang,and 5 cases of yin-exhaustion depleting yang.The levels of Cys-C and CA125 of patients with different TCM syndrome in the observation group were significantly higher than those in the control group(P<0.05).The difference was statistically significant in Cys-C and CA125 between patients with yin-exhaustion depleting yang syndromes and those with other TCM syndromes in the observation group(P<0.05).Spearman correlation coefficient test showed a positive correlation between Cys-C and CA12 in CHF patients(r=0.602,P=0.001).Logistic regression analysis showed was a correlation between different TCM syndrome types with Cys-C and CA125 levels in CHF patients(both P<0.05).Conclusion The levels of serum Cys-C and CA125 in CHF patients are generally increased,and with a correlation with different TCM syndromes types.It can be used as the observation indexes for the determination of CHF syndrome type,and provides reference for clinical treatment plan.