应用达格列净加沙库巴曲缬沙坦治疗2型糖尿病合并心力衰竭的效果探讨观察

Exploring and Observing the Effectiveness of Applying Dapagliflozin Plus Sacubitril Valsartan in the Treatment of Heart Failure Combined with Type 2 Diabetes

目的观察应用达格列净加沙库巴曲缬沙坦治疗2型糖尿病合并心力衰竭的临床疗效。方法选取2020年1月—2021年1月期间在山东省滨州市无棣县人民医院心内科治疗的96例2型糖尿病合并心力衰竭患者为研究对象,按入院时间分为常规组(48例)和研究组(48例)。常规组采用沙库巴曲缬沙坦联合二甲双胍缓释片治疗,研究组在常规组基础上联合达格列净治疗,对比两组患者血糖生化指标、不良反应发生率。结果研究组FPG、2 hPG、HbA1c、HOMA-β、HOMA-IR均优于常规组,差异有统计学意义(P<0.05)。研究组患者不良反应发生率(6.25%)低于常规组(29.16%),差异有统计学意义(P<0.05)。结论达格列净加沙库巴曲缬沙坦治疗2型糖尿病合并心力衰竭患者,可以降糖减脂,有效提升患者的生存质量。

Objective To observe the clinical efficacy of applying dapagliflozin plus sacubitril valsartan in the treatment of heart failure combined with type 2 diabetes mellitus.Methods 96 patients with type 2 diabetes complicated with heart failure who were treated in the Department of Cardiology of Wudi County People's Hospital,Binzhou,Shandong Province from January 2020 to January 2021 were selected as the research objects.They were divided into the routine group(48 cases)and the study group(48 cases)according to the time of admission.The routine group was treated with sarcubatrox Valsartan combined with Metformin sustained-release tablets,and the study group was treated with on the basis of routine group combined with Dapagliflozin.The blood glucose biochemical indicators,cardiac function indicators,and the incidence of adverse reactions were compared between the two groups.Results Before treatment,there was no statistically significant difference in blood glucose biochemical indicators between the two groups of patients(P>0.05).After treatment,the study group had FPG,2 hPG,HbA1c,HOMA-β,HOMA-IR was superior to the conventional group,the difference was statistically significant(P<0.05).The incidence of adverse reactions in the study group(6.25%)was lower than that in the conventional group(29.16%),the difference was statistically significant(P<0.05).Conclusion Dapagliflozin plus sacubitril valsartan in the treatment of patients with type 2 diabetes mellitus combined with heart failure can lower glucose and reduce fat,which effectively improves the quality of survival of patients.