1,4-酸钠合成技术进展

Advances in Synthesis of 1-Amino-4-Naphthalene Sulfonate Sodium

1,4-酸钠(1-氨基-4-茶磺酸钠)是一种重要的染料、医药及其它化工中间体,也可作为亚硝酸盐和碘中毒的解药。1,4-酸钠络合物还可用于化学检测、临床医学研究等。目前1,4-酸钠的生产工艺大多数采用甲茶胺固相烘焙间歇磺化法,车间操作条件差、能耗大且产率低。本研究介绍了有关1,4-酸钠的制备工艺,包括1-硝基茶还原磺化法、甲茶胺固相烘焙磺化法、甲茶胺液相磺化法。1-硝基茶还原磺化法工艺简单,但是需要提高收率。甲茶胺连续固相烘焙磺化法值得推荐。高沸点溶剂中的液相磺化法也是1,4-酸钠生产工艺的改进方向。甲茶胺液相磺化法物料混合均匀、温度易于控制、收率较高,所使用的溶剂主要为邻二氯苯、均四甲苯、均三甲苯等,且可以回收利用。

1,4-Acidic sodium(sodium 1-amino-4-naphthalene sulfonate)is an important intermediate for dyes,medicine,etc.And it can be also as a key antidote of nitrite as well as iodine.The complex of 1,4-acidic sodium can be studied for chemical detection and clinical research.The most production method of 1,4-acidic sodium at present is the process of batch baking sulfonation of 1-naphthylamine.However,this batch baking process is associated with various problems,such as poor work condition,high energy consumption and low yield.The preparation processes of 1,4-acidic sodium,such as reduction-sulfonation of 1-nitronaphthalene,solid baking sulfonation of 1-naphthylamine,liquid sulfonation of 1-naphthylamine were reviewed.The yield of reduction-sulfonation of 1-nitronaphthalene needed to be improved although the process was simple.The continuous solid-phase baking sulfonation method of 1-naphthylamine was worth of recommendation.Liquid sulfonation in high boiling solvent should be also a development process.In the process of liquid sulfonation,the reaction mixtures were stirred evenly,temperature was controlled easily,the yield was higher.O-Dichlorobenzene,durene,mesitylene were selected as the solvents.The solvents could be recycled after distillation.