动脉粥样硬化小鼠模型应用进展

Progress in the application of arteriosclerosis mouse models

动脉粥样硬化(arteriosclerosis, AS)是常见的心脏病和中风等心脑血管疾病的病理基础,其诱因具有复杂、多样的特点。小鼠模型凭借成熟的基因改造优势,为研究AS发病机制和药物疗效验证等方面提供了重要依据。本文基于脂蛋白代谢及组织病理学变化情况,综述了传统转基因与新型小鼠模型的病理特点及其在药物开发中的临床前应用潜力和局限性,以便今后该疾病相关机制研究可以有针对性地选择模型。

Atherosclerosis(AS)is the pathological basis of common cardiovascular diseases such as heart disease and stroke,and its causative factors are complex and diverse.With the advancement of mature genetic modifications,mouse models have provided an important basis to study the pathogenesis of AS and validating drug efficacy.In this article,we review the pathological characteristics of traditional transgenic and novel mouse models on the basis of lipoprotein metabolism and histopathological changes,as well as their potential and limitations for preclinical application in drug development,so that future studies on mechanisms related to this disease can be targeted to select models.