摘要
骨肉瘤是最常见的原发性实体骨恶性肿瘤,化疗药物的耐药是导致骨肉瘤复发和转移的重要因素。长非编码RNA可通过调节上皮间质转化、细胞自噬、凋亡、药物外排、细胞周期等途径影响骨肉瘤耐药,提示长非编码RNA可能成为治疗骨肉瘤耐药的新靶点。
Osteosarcoma is the most common primary solid bone malignancy.The main factor leading to recurrence and metastasis of osteosarcoma is resistance to chemotherapy drugs.Long non-coding RNAs can affect drug resistance in osteosarcoma by regulating epithelial-mesenchymal transition,cell autophagy,apoptosis,drug efflux,and cell cycle,suggesting that long non-coding RNAs may become new targets for drug resistance in osteosarcoma treatment.
作者
马小平
常君丽
孙星媛
杨燕萍
Ma Xiaoping;Chang Junli;Sun Xingyuan;Yang Yanping(Spine Disease Research Institute,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine/Key Laboratory of Theory and Therapy of Muscles and Bones,Ministry of Education,Shanghai 200032,China)
出处
《国际肿瘤学杂志》
CAS
2023年第1期51-54,共4页
Journal of International Oncology
基金
国家重点研发计划(2018YFC1704300、2020YFE0201600)
国家自然科学基金(81973877、82174408)。
关键词
RNA
长链非编码
骨肉瘤
抗药性
肿瘤
RNA,long non-coding
Osteosarcoma
Drug resistance,neoplasms
