摘要
We report a KOtBu-catalyzed α-homoallylic alkylation of lactams with 1,3-dienes. With this transitionmetal-free and atom-economical protocol, a variety of α-homoallylic alkylated lactams bearingα-quaternary carbon centers were formed in a 2,1-addition manner with excellent regioselectivity. Acation–π interaction between the in situ-generated potassium enolate and the diene is proposed to play akey role in accelerating this transformation.
基金
support from the National Natural Science Foundation of China(21772043)
the Shanghai Pujiang Program(No.19PJ1403000)is greatly acknowledged.
