癫痫与皮质扩散性抑制相关性研究进展

Advances on the correlation between epilepsy and cortical spreading depression

皮质扩散性抑制是神经元集体去极化在大脑皮质中传播的病理去极化波,沿大脑皮质缓慢传播,可短暂性抑制脑电活动,与多种发作性脑病相关。皮质扩散性抑制与痫样放电是共同发生的电生理现象,引起皮质扩散性抑制的因素亦可诱发癫痫发作;抑制皮质扩散性抑制的发生、传播可改变癫痫发作阈值,减少癫痫发作,二者相互联系、相互影响。本文综述癫痫与皮质扩散性抑制的相关性研究进展,以提高临床对二者相关性的认识。

Cortical spreading depression(CSD)is a pathological depolarization wave caused by the collective depolarization of neurons that propagates slowly along the cerebral cortex and can transiently inhibit brain electrical activity,which is related to a variety of paroxysmal encephalopathy.CSD and epileptiform discharge are co-occurring electrophysiological phenomena.Factors causing CSD can also induce epileptic seizure.Inhibiting the occurrence and propagation of CSD may change the seizure threshold and reduce epileptic seizure,and the two are interrelated and interact on each other.This article reviews the research progress of the correlation between epilepsy and CSD,in order to improve the clinical understanding of the correlation between them.