中医五音疗法辅助干预脑卒中疗效的Meta分析

Meta-Analysis of the Efficacy of Traditional Chinese Medicine Five-Tone Therapy as an Auxiliary Intervention for Stroke

目的:系统评价中医五音疗法辅助干预脑卒中患者的临床疗效。方法:检索知网(CNKI)、万方(Wanfang)数据库、维普数据库(VIP)、中国生物医学文献数据库(CBM)、PubMed、WebofScience数据库中有关中医五音疗法辅助干预脑卒中患者的随机对照试验,检索时间为建库至2022年9月。由2名研究员独立筛选文献,采用Cochrane协作网的偏倚风险评价工具对纳入的文献质量进行评价,运用RevMan5.3进行统计学分析。结果:共纳入17篇RCT及1 422例患者。Meta分析结果显示:脑卒中患者睡眠质量PSQI量表评分试验组与对照组相比,差异有统计学意义[MD=-3.30,95%CI(-3.80,-2.80),P<0.000 01];脑卒中患者负性情绪HAMD量表评分试验组与对照组相比,差异有统计学意义[MD=-2.21,95%CI(-2.47,-1.95),P<0.000 01];脑卒中伴睡眠障碍患者临床治疗有效率试验组与对照组比较,差异有统计学意义[OR=3.34,95%CI(2.08,5.37),P<0.000 01];脑卒中伴负性情绪患者临床治疗有效率试验组与对照组比较,差异有统计学意义[OR=4.18,95%CI(2.42,7.20),P<0.000 01]。结论:中医五音疗法辅助干预可改善脑卒中患者的睡眠质量和负性情绪。

Objective:To systematically evaluate the clinical efficacy of traditional Chinese medicine five-tone therapy as an auxiliary intervention for stroke patients.Methods:Randomized controlled trials on TCM five-tone therapy assisted intervention in stroke patients were retrieved from CNKI,Wanfang,VIP,CBM,PubMed and Web of Science.The retrieval time was from the establishment of the database to September 2022.The literature was screened independently by two researchers,and the quality of the included literature was evaluated using the bias risk assessment tool of the Cochrane Collaboration network.RevMan5.3 was used for statistical analysis.Results:A total of 17 RCTS and 1422 patients were included.The results of Meta-analysis showed that there was a statistically significant difference in the sleep quality PSQI scale score between the experimental group and the control group in stroke patients[MD=-3.30,95%CI(-3.80,-2.80),P<0.00001];there was a statistically significant difference in the negative emotion HAMD scale score between the experimental group and the control group in stroke patients[MD--2.21,95%CI(-2.47,-1.95),P<0.00001];the clinical treatment effectiveness rate of stroke patients with sleep disorders was significantly different between the experimental group and the control group[0R=3.34,95%CI(2.08,5.37),P<0.00001];the clinical treatment effectiveness rate of stroke patients with negative emotions was significantly different between the experimental group and the control group[OR=4.18,95%CI(2.42,7.20),P<0.00001].Conclusion:The auxiliary intervention of traditional Chinese medicine five-tone therapy can improve the sleep quality and negative emotions of stroke patients.