类风湿关节炎大小鼠动物模型研究进展

Research progress in rat and mouse animal models of rheumatoid arthritis

类风湿关节炎是慢性、以滑膜炎为主的全身免疫性疾病,致残率高,且发病机制不明确。因此,找到与人类关节炎相似的动物模型对研究该疾病的发病机制及治疗至关重要。而类风湿关节炎的大小鼠模型虽趋于成熟,但有很多种,有利有弊。根据情况找到合适的模型可便于建立动物模型,提高成功率。本文介绍了几种常见模型,佐剂诱导性关节炎模型和胶原诱导性关节炎模型最为常用,此外还有胶原抗体诱导性关节炎模型、降植烷诱导的关节炎模型、软骨寡聚基质蛋白诱导的关节炎模型、链球菌胞壁诱导的关节炎模型及基因工程型类风湿关节炎模型,以期为类风湿关节炎的相关实验提供有益参考。

Rheumatoid arthritis is a chronic,systemic immune disease mainly characterized by synovitis,with a high disability rate and an unclear pathogenesis.Therefore,finding animal models similar to human arthritis is crucial for studying the pathogenesis and treatment of the disease.There are many different models of rheumatoid arthritis in mice and rats,although they are well established,and there are advantages and disadvantages.Finding suitable models according to the situation can facilitate the establishment of animal models and improve the success rate.This article introduces several common models,adjuvant induced arthritis models and collagen-induced arthritis models are most commonly used.In addition,there are models of collagen antibodies induced arthritis,pristane induced arthritis,cartilage oligomeric matrix protein induced arthritis,streptococcal cell wall induced arthritis,and genetically engineered rheumatoid arthritis,in order to provide useful references for experiments related to rheumatoid arthritis.