重组人干扰素α2b联合1,6-二磷酸果糖治疗儿童轮状病毒肠炎的效果及心肌保护作用

Effects of recombinant human interferon α2b combined with fructose 1,6-diphosphate on rotavirus enteritis in children and myocardial protection

目的 探究重组人干扰素α2b(RHIα2b)联合1,6-二磷酸果糖(FDP)治疗儿童轮状病毒肠炎(RVE)的效果及心肌保护作用。方法 选取安徽省淮南市第一人民医院2019年6月至2022年6月收治的78例RVE患儿,按照随机数字表法分为两组,各39例。对照组采用RHIα2b治疗,观察组采用RHIα2b联合FDP治疗。治疗7 d后评估两组临床疗效,比较两组治疗前后免疫功能及心肌谱酶水平,比较两组住院时间、止泻时间及脱水纠正时间,观察两组不良反应发生情况。结果 观察组临床疗效优于对照组(P<0.05)。治疗后,两组CD3+、CD4+/CD8+水平高于治疗前,且观察组高于对照组(P<0.05)。治疗后,两组肌酸激酶、肌酸激酶同工酶及乳酸脱氢酶水平低于治疗前,且观察组低于对照组(P<0.05)。观察组住院时间、止泻时间短于对照组(P<0.05);两组脱水纠正时间比较,差异无统计学意义(P>0.05)。两组用药过程中均未见皮疹、发热、心悸等不良反应。结论 RHIα2b联合FDP能够提高RVE患儿的治疗效果,改善免疫功能,对患儿心肌起到一定的保护作用,加速患儿康复,安全有效。

Objective To explore the effects of recombinant human interferonα2b(RHIα2b)combined with fructose 1,6-diphosphate(FDP)on rotavirus enteritis(RVE)in children and myocardial protection.Methods A total of 78 children with RVE who admitted to Huainan First People’s Hospital from June 2019 to June 2022 were selected,they were divided into two groups,with 39 cases in each group.The control group was treated with RHIα2b,and the observation group was treated with RHIα2b combined with FDP.The clinical efficacy of two groups was evaluated after seven days of treatment,the immune function and myocardial enzyme levels were compared between two groups before and after treatment,the hospitalization time,antidiarrheal time,and dehydration correction time of two groups were compared,the occurrence of adverse reactions in two groups was observed.Results The clinical effect of observation group was better than that of control group(P<0.05).After treatment,the levels of CD3+and CD4+/CD8+in observation group were higher than those before treatment,and observation group was higher than control group(P<0.05).After treatment,the levels of creatine kinase,creatine kinase MB,and lactate dehydrogenase in two groups were lower than those before treatment,and observation group was lower than the control group(P<0.05).The hospitalization time and antidiarrheal time in observation group were shorter than those in control group(P<0.05);there was no significant difference in dehydration correction time between two groups(P>0.05).No adverse reactions such as rash,fever,and palpitation were found in the two groups.Conclusion RHIα2b combined with FDP can improve the therapeutic effect of RVE in children,improve the immune function,play a certain protective effect on the heart muscle of children,accelerate the recovery of children,safe,and effective.