基于数据挖掘研究陈柏楠教授治疗下肢慢性静脉功能不全的用药规律

Study on medication rules of Professor Chen Bainan in treating chronic venous insufficiency of lower limbs based on data mining

目的总结陈柏楠教授治疗下肢慢性静脉功能不全(CVI)的用药规律。方法搜集陈柏楠教授2017年1月至2022年3月于山东中医药大学附属医院周围血管病科门诊治疗CVI的临床处方,运用频次分析、关联规则分析、拓扑数据分析、聚类分析方法,分析药物频次、性味归经、新方构建和药物组合,探讨其用药规律。结果本研究共搜集到符合纳入标准处方520首,中药152味,其中高频中药35味;高频药类为清热药、活血祛瘀药、补虚药,药性多为寒或温,味苦、辛或甘,主入肝经;分析获得强关联规则24条,构建新方1首,得到聚类组合3组。结论陈柏楠教授治疗CVI的用药规律为活血解毒,兼顾扶正,主张调畅气机,调气活血,重视湿邪,擅长灵活祛湿。

Objective To summarize the medication rules of Professor Chen Bainan in treating chronic venous insufficiency(CVI)of lower limbs.Methods The clinical prescriptions of Professor Chen Bainan for the treatment of CVI in the Outpatient Department of Peripheral Vascular Disease,Affiliated Hospital of Shandong University of Traditional Chinese Medicine from January 2017 to March 2022 were collected.The methods of frequency analysis,association rule analysis,topological data analysis,and cluster analysis were used to analyze drug frequency,nature and flavour,channel tropism,new prescription construction,and drug combination,and to explore the rule of drug use.Results A total of 520 prescriptions were collected in this study,including 152 traditional Chinese medicine,among which 35 were high-frequency traditional Chinese medicine.High-frequency drugs were clearing heat drugs,promoting blood circulation for removing blood stasis drugs,tonifying drugs.The drug natures were mostly cold or warm,the drug flavours were bitter,pungent or sweet,the drugs main into the liver channel.A total of 24 strong association rules were obtained,one new formula was constructed,and and three cluster combinations were obtained.Conclusion Professor Chen Baonan’s medication rules for CVI treatment is to promote blood and detoxification,taking into account strengthening vital qi,advocating the regulation of qi movement,regulating qi and activating blood,paying attention to dampness pathogen,and being good at removing dampness flexibly.