老年脑卒中伴抑郁患者使用草酸艾司西酞普兰联合康复训练治疗的效果

Effect of escitalopram oxalate combined with rehabilitation training in elderly stroke patients with depression

目的:探讨老年脑卒中伴抑郁患者使用草酸艾司西酞普兰联合康复训练治疗的效果。方法:采用回顾性分析法选择2020年5月至2022年5月解放军联勤保障部队第904医院收治的老年脑卒中伴抑郁患者114例,行草酸艾司西酞普兰治疗的57例患者为对照组,在对照组基础上联合康复训练治疗的57例为研究组。2组均治疗8周,对比治疗前后神经功能、抑郁情绪、认知功能、免疫功能变化情况,并统计不良反应发生率。结果:研究组治疗8周后美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale,NIHSS)评分、汉密尔顿抑郁量表(Hamilton Depression Scale,HAMD)评分均较对照组低(均P<0.05);研究组治疗8周后简易精神状态量表(Mini-Mental State Examination,MMSE)各维度评分均较对照组高(均P<0.05);研究组治疗8周后免疫球蛋白(immunoglobulin,Ig)G、IgM、IgA均较对照组高(均P<0.05);研究组总不良反应发生率与对照组相比,差异无统计学意义(P>0.05)。结论:老年脑卒中伴抑郁患者使用草酸艾司西酞普兰联合康复训练治疗可改善其神经功能及认知功能,减轻抑郁情绪,提升免疫功能,且不良反应发生率低。

Objective:To investigate the effect of escitalopram oxalate combined with rehabilitation training in elderly stroke patients with depression.Methods:A retrospective analysis was carried out in 102 middle-aged and elderly patients with severe diseases admitted to neurosurgery in 904 Hospital of PLA Joint Logistic Support Force from May 2020 to May 2022,51 patients who received early standard dose enteral nutrition as the control group,and 51 patients who received early low dose enteral nutrition as the study group.Both groups were treated for 8 weeks,and the changes in neurological function,depression,cognitive function,and immune function before and after treatment were compared,and the incidence of adverse reactions was counted.Results:After 8 weeks of treatment,the National Institutes of Health Stroke Scale(NIHSS)and Hamilton Depression Scale(HAMD)scores in the study group were lower than those in the control group(P<0.05);the scores of all dimensions of Mini-Mental State Examination(MMSE)in the study group were higher than those in the control group after 8 weeks of treatment(all P<0.05).After 8 weeks of treatment,the immunoglobulin(Ig)G,IgM,and IgA levels in the study group were higher than those in the control group(all P<0.05).There was no statistically significant difference in the incidence of reaction compared with the control group(P>0.05).Conclusion:The use of escitalopram oxalate combined with rehabilitation training in elderly stroke patients with depression can improve their neurological function and cognitive function,reduce depression,improve immune function,and have low incidence of adverse reactions.