盐酸雷尼替丁联合奥曲肽对急性胰腺炎的疗效

Effect of Ranitidine Hydrochloride combined with Octreotide on acute Pancreatitis

目的探讨盐酸雷尼替丁胶囊联合奥曲肽注射液对重症急性胰腺炎(SAP)患者疗效及对血清炎症因子水平的影响。方法选取许昌市北海医院2021年2月至2022年5月收治的116例SAP患者,随机且均等分为对照组和联合组(各58例)。对照组在常规基础治疗的基础上给与奥曲肽注射液治疗,联合组则在对照组的基础上给予盐酸雷尼替丁胶囊,分析两组患者治疗后疗效、临床症状消失或恢复正常时间,检测治疗前后血、尿淀粉酶水平、白细胞计数(WBC)和C-反应蛋白(CRP)表达情况以及血清炎症因子(IL-6及IL-8、TNF-α和IL-10)水平。结果联合组的治疗有效率(91.38%)高于对照组(77.59%),差异有统计学意义(P<0.05)。联合组腹痛消失时间、腹胀消失时间及血淀粉酶、胃肠功能恢复正常时间短于对照组,差异有统计学意义(P<0.05)。治疗后,两组患者的血淀粉酶水平、尿淀粉酶水平、WBC、CRP、血清炎症因子表达水平优于治疗前,且联合组优于对照组,差异有统计学意义(P<0.05)。结论盐酸雷尼替丁胶囊联合奥曲肽注射液在治疗SAP患者中应用疗效肯定,其可促进腹痛腹胀消失、血淀粉酶和胃肠功能的恢复,并可调节血淀粉酶、尿淀粉酶、WBC、CRP及血清炎症因子表达水平。

Objective To investigate the therapeutic effect of ranitidine hydrochloride combined with octreotide injection on patients with severe acute pancreatitis(SAP)and its influence on serum inflammatory factors.Methods A total of 116 SAP patients admitted to Beihai Hospital of Xuchang from February 2021 to May 2022 were randomly divided into control group and combination group(58 cases each).The control group was treated with octreotide injection on the basis of routine basic treatment,and the combined group was treated with ranitidine hydrochloride capsule on the basis of the control group.The efficacy of the two groups of patients after treatment,the time when clinical symptoms disappeared or returned to normal,the blood and urine amylase levels,white blood cell count(WBC),C-reactive protein(CRP)expression,and serum inflammatory factors(IL-6,IL-8,TNF-αand IL-10)were analyzed before and after treatment.Results The treatment effective rate of the combination group(91.38%)was higher than that of the control group(77.59%),with a statistically significant difference(P<0.05).The disappearance time of abdominal pain,abdominal distension,blood amylase and gastrointestinal function in the combined group were shorter than those in the control group,the difference was statistically significant(P<0.05).After treatment,the levels of blood amylase,urine amylase,WBC,CRP,and serum inflammatory factors in the two groups were better than those before treatment,and the combined group was better than the control group,with a statistically significant difference(P<0.05).Conclusions The combination of ranitidine hydrochloride capsules and octreotide injection in the treatment of SAP patients has a positive effect.It can promote the disappearance of abdominal pain and abdominal distention,the recovery of blood amylase and gastrointestinal function,and regulate the expression levels of blood amylase,urine amylase,WBC,CRP and serum inflammatory factors.