三维五感多靶向疗法治疗“植物人”疗效评价

Evaluation of the effect of three-dimensional five sense multi-target therapy on vegetative patients

目的观察三维五感多靶向疗法治疗“植物人”的临床疗效,并分析其对临床疗效的影响。方法选择2017年11月至2020年11月西安中医脑病医院“植物人”中医重点研究室收治的45例确诊为“植物人”的患者,将患者分为治疗组23例(三维五感多靶向治疗)和对照组22例(西医药物治疗)。两组均于治疗前及治疗1个月后进行改良国际昏迷恢复量表(CRS-R)评估、长程脑电图(EEG)、脑干听觉诱发电位(BAEP)检查,综合分析评估分值的变化。结果治疗前,两组CRS-R评分、EEG分级及其秩均数、BAEP分级及其秩均数比较差异均无统计学意义。治疗后,两组CRS-R评分均较治疗前明显升高,EEG和BAEP分级改善程度均优于治疗前;且治疗组CRS-R评分明显高于对照组(分:8.30±1.48比5.65±1.45,P<0.05),EGG秩均数和BAEP秩均数均明显低于对照组(EGG秩均数:32.5比57.3,BAEP秩均数:30.08比48.73,均P<0.05)。结论三维五感多靶向疗法在治疗“植物人”方面具有明显疗效,且CRS-R、EEG、BAEP评价方法对植物疗效有一定判断价值。

Objective To observe the clinical efficacy of three-dimensional five sense multi-target therapy in the treatment of vegetative patient,and to analyze the effect of its clinical effect.Methods From November 2017 to November 2020,45 patients diagnosed as vegetative state were selected and treated in the Botanical Chinese Medicine Key Research Office of Xi'an Traditional Chinese Medicine Encephalopathy Hospital.The patients were divided into the treatment group of 23 patients(three-dimensional five sense multi-target therapy)and the control group of 22 patients(Western medicine treatment).Both groups were evaluated and analyzed with the modified international coma recovery scale(CRS-R),long-term electroencephalogram(EEG),and brainstem auditory evoked potential(BAEP)before and 1 month after treatment.Results Before treatment,there was no statistically significant difference between the two groups in terms of CRS-R score,EEG grading,and BAEP grading and rank mean.After treatment,the CRS-R scores of both groups were significantly higher than before treatment,and the improvement of EEG and BAEP grading was better than before treatment.Moreover,the CRS-R score in the treatment group was significantly higher than that in the control group(score:8.30±1.48 vs.5.65±1.45,P<0.05),and the mean EGG rank and the mean BAEP rank were significantly lower than those in the control group(EGG rank mean:32.5 vs.57.3,BAEP rank mean:30.08 vs.48.73,both P<0.05).Conclusion Three dimensional five sense multi-target therapy has obvious curative effect in treating vegetative patient,and the evaluation methods of CRS-R,EEG,and BAEP have certain value in judging the curative effect of plants.