摘要
急性肾损伤(AKI)的主要病理特征是肾脏毛细血管内皮损伤引起的血管功能障碍、强烈的炎症反应和肾小管上皮细胞(TEC)损伤。细胞焦亡是由内源性细胞损伤〔损伤相关分子模式(DAMPs)〕或外源性细菌、病毒〔病原体相关分子模式(PAMPs)〕激活炎症小体相继引发下游信号活跃度增加的级联放大反应,是可导致细胞膜破坏且内容物大量释放的一种区别于凋亡的细胞死亡方式。近年来焦亡与AKI的关系也不断被报道且广受关注。现重点对细胞焦亡的分子机制及细胞焦亡与AKI关系的相关研究成果进行综述,以期为今后临床医生防治AKI提供帮助。
The main pathological features of acute kidney injury(AKI)are vascular dysfunction caused by renal capillary endothelial injury,strong inflammatory response,and renal tubular epithelial cell(TEC)injury.Pyroptosis is a cascade amplification in which inflammasomes are activated by endogenous cell[damage-associated molecular patterns(DAMPs)]or exogenous bacteria and viruses[pathogen-associated molecular patterns(PAMPs)].Reaction is a cell death method that is different from apoptosis,which can lead to the destruction of cell membrane and the release of a large amount of content.In recent years,the relationship between Pyroptosis and AKI has been continuously reported and widely concerned.This paper focuses on the molecular mechanism of pyroptosis and the related research results on the relationship between pyroptosis and AKI,in order to provide help for clinicians in the prevention and treatment of AKI in the future.
作者
王敏
张利鹏
Wang Min;Zhang Lipeng(Department of Critical Care Medicine,the Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010000,Inner Mongolia Autonomous Region,China)
出处
《中国中西医结合急救杂志》
CAS
CSCD
北大核心
2023年第1期117-120,共4页
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
基金
内蒙古自然基金项目(2018MS08093)
内蒙古自治区卫生和计划生育委员会课题(201703105)
内蒙古医科大学科技百万工程项目(YKD2016KJBW004)
内蒙古医科大学附属医院博士启动项目(NYFYBS202105)。
